中华临床免疫和变态反应杂志
中華臨床免疫和變態反應雜誌
중화림상면역화변태반응잡지
CHINESE JOURNAL OF ALLERGY & CLINICAL IMMUNOLOGY
2015年
2期
91-95
,共5页
刘赫%朱庆莉%侯勇%徐东%李梦涛%姜玉新%李建初%曾小峰%张奉春
劉赫%硃慶莉%侯勇%徐東%李夢濤%薑玉新%李建初%曾小峰%張奉春
류혁%주경리%후용%서동%리몽도%강옥신%리건초%증소봉%장봉춘
系统性硬化症%皮肤厚度%高频超声
繫統性硬化癥%皮膚厚度%高頻超聲
계통성경화증%피부후도%고빈초성
systemic sclerosis%skin thickness%high frequency ultrasound
目的:探讨高频超声测量皮肤厚度在弥漫性系统性硬化症中的应用价值。方法应用高频超声对12例弥漫性系统性硬化症患者和12例年龄、性别匹配的正常对照者分别测量全身17个部位的表皮、真皮及皮肤(包括表皮和真皮)厚度,比较两组间各部位表皮、真皮及皮肤厚度有无差异。17个部位包括双侧指背、手背、前臂、上臂、大腿、小腿、足背及前额、胸壁、腹壁。并分别比较正常对照、临床 Rodnan 皮肤评分0、1、2、3各组间表皮、真皮及皮肤厚度有无差异。结果弥漫性系统性硬化症患者双侧指背[右:0.600(0.200)mm 比0.500(0.200)mm;左:0.550(0.250)mm 比0.500(0.100)mm]、手背[右:1.200(0.700)mm 比0.500(0.200)mm;左:0.750(0.625)mm 比0.500(0.175)mm]、前臂[右:0.800(1.225)mm 比0.500(0.175)mm;左:0.650(0.575)mm 比0.500(0.200)mm]、足背[右:0.750(0.65)mm比0.800(0.525)mm;左:0.550(0.625)mm 比0.400(0.100)mm]及左上臂[0.650(0.300)mm 比0.500(0.100)mm]的真皮厚度高于正常对照组;双侧指背[右:1.000(0.250)mm 比0.800(0.275)mm;左:1.000(0.400)mm 比0.800(0.275)mm]、手背[右:1.550(0.925)mm 比0.800(0.275)mm;左:1.200(0.700)mm 比0.800(0.300)mm]、前臂[右:1.150(1.200)mm 比0.800(0.275)mm;左:1.250(0.850)mm 比0.800(0.300)mm]及足背[右:1.200(0.925)mm比1.150(0.450)mm;左:0.800(0.900)mm 比0.700(0.200)mm]的皮肤厚度高于正常对照组,差异有统计学意义(P <0.05)。Rodnan 皮肤评分1、2、3的表皮、真皮及皮肤厚度均高于正常对照组。Rodnan 皮肤评分1、2的真皮及皮肤厚度和Rodnan 评分2的表皮厚度均高于评分0组。结论高频超声测量皮肤厚度有助于评估弥漫性系统性硬化症患者的皮肤改变。
目的:探討高頻超聲測量皮膚厚度在瀰漫性繫統性硬化癥中的應用價值。方法應用高頻超聲對12例瀰漫性繫統性硬化癥患者和12例年齡、性彆匹配的正常對照者分彆測量全身17箇部位的錶皮、真皮及皮膚(包括錶皮和真皮)厚度,比較兩組間各部位錶皮、真皮及皮膚厚度有無差異。17箇部位包括雙側指揹、手揹、前臂、上臂、大腿、小腿、足揹及前額、胸壁、腹壁。併分彆比較正常對照、臨床 Rodnan 皮膚評分0、1、2、3各組間錶皮、真皮及皮膚厚度有無差異。結果瀰漫性繫統性硬化癥患者雙側指揹[右:0.600(0.200)mm 比0.500(0.200)mm;左:0.550(0.250)mm 比0.500(0.100)mm]、手揹[右:1.200(0.700)mm 比0.500(0.200)mm;左:0.750(0.625)mm 比0.500(0.175)mm]、前臂[右:0.800(1.225)mm 比0.500(0.175)mm;左:0.650(0.575)mm 比0.500(0.200)mm]、足揹[右:0.750(0.65)mm比0.800(0.525)mm;左:0.550(0.625)mm 比0.400(0.100)mm]及左上臂[0.650(0.300)mm 比0.500(0.100)mm]的真皮厚度高于正常對照組;雙側指揹[右:1.000(0.250)mm 比0.800(0.275)mm;左:1.000(0.400)mm 比0.800(0.275)mm]、手揹[右:1.550(0.925)mm 比0.800(0.275)mm;左:1.200(0.700)mm 比0.800(0.300)mm]、前臂[右:1.150(1.200)mm 比0.800(0.275)mm;左:1.250(0.850)mm 比0.800(0.300)mm]及足揹[右:1.200(0.925)mm比1.150(0.450)mm;左:0.800(0.900)mm 比0.700(0.200)mm]的皮膚厚度高于正常對照組,差異有統計學意義(P <0.05)。Rodnan 皮膚評分1、2、3的錶皮、真皮及皮膚厚度均高于正常對照組。Rodnan 皮膚評分1、2的真皮及皮膚厚度和Rodnan 評分2的錶皮厚度均高于評分0組。結論高頻超聲測量皮膚厚度有助于評估瀰漫性繫統性硬化癥患者的皮膚改變。
목적:탐토고빈초성측량피부후도재미만성계통성경화증중적응용개치。방법응용고빈초성대12례미만성계통성경화증환자화12례년령、성별필배적정상대조자분별측량전신17개부위적표피、진피급피부(포괄표피화진피)후도,비교량조간각부위표피、진피급피부후도유무차이。17개부위포괄쌍측지배、수배、전비、상비、대퇴、소퇴、족배급전액、흉벽、복벽。병분별비교정상대조、림상 Rodnan 피부평분0、1、2、3각조간표피、진피급피부후도유무차이。결과미만성계통성경화증환자쌍측지배[우:0.600(0.200)mm 비0.500(0.200)mm;좌:0.550(0.250)mm 비0.500(0.100)mm]、수배[우:1.200(0.700)mm 비0.500(0.200)mm;좌:0.750(0.625)mm 비0.500(0.175)mm]、전비[우:0.800(1.225)mm 비0.500(0.175)mm;좌:0.650(0.575)mm 비0.500(0.200)mm]、족배[우:0.750(0.65)mm비0.800(0.525)mm;좌:0.550(0.625)mm 비0.400(0.100)mm]급좌상비[0.650(0.300)mm 비0.500(0.100)mm]적진피후도고우정상대조조;쌍측지배[우:1.000(0.250)mm 비0.800(0.275)mm;좌:1.000(0.400)mm 비0.800(0.275)mm]、수배[우:1.550(0.925)mm 비0.800(0.275)mm;좌:1.200(0.700)mm 비0.800(0.300)mm]、전비[우:1.150(1.200)mm 비0.800(0.275)mm;좌:1.250(0.850)mm 비0.800(0.300)mm]급족배[우:1.200(0.925)mm비1.150(0.450)mm;좌:0.800(0.900)mm 비0.700(0.200)mm]적피부후도고우정상대조조,차이유통계학의의(P <0.05)。Rodnan 피부평분1、2、3적표피、진피급피부후도균고우정상대조조。Rodnan 피부평분1、2적진피급피부후도화Rodnan 평분2적표피후도균고우평분0조。결론고빈초성측량피부후도유조우평고미만성계통성경화증환자적피부개변。
Objective To investigate the utility of high frequency ultrasound measurement of skin thickness in diffuse cutaneous systemic sclerosis(dcSSc).Methods Twelve patients with dcSSc and 12 age and sex matched controls were recruited.The thickness of epidermis, dermis, and full skin (including both epidermis and dermis)were measured by high frequency ultrasound and the skin thickness was compared between dcSSc patients and healthy controls at 17 sites.The 17 sites were bilateral middle fingers,hand dorsum,forearms,upper arms,thigh,lower legs,foot dorsum,forehead,anterior chest,and anterior abdomen.The thickness of epidermis,dermis and full skin were compared between controls,clinical Rodnan skin score 0,1,2 and 3.Results The dermis of bilateral finger [right:0.600 (0.200)mm vs.0.500(0.200)mm;left:0.550(0.250)mm vs.0.500(0.100)mm],hand dorsum [right:1.200 (0.700)mm vs.0.500(0.200)mm;left:0.750(0.625)mm vs.0.500(0.175)mm],forearm [right:0.800(1.225 )mm vs.0.500 (0.175 )mm;left:0.650 (0.575 )mm vs.0.500 (0.200)mm],foot dorsum [right:0.750(0.65)mm vs.0.800(0.525)mm;left:0.550(0.625)mm vs.0.400(0.100) mm]and left upper arm [0.650(0.300)mm vs.0.500(0.100)mm]was thicker in dcSSc patients than controls.The full skin of bilateral finger [right:1.000(0.250)mm vs.0.800(0.275)mm;left:1.000 (0.400)mm vs.0.800(0.275)mm],hand dorsum [right:1.550(0.925)mm vs.0.800(0.275)mm;left:1.200(0.700 ) mm vs.0.800 (0.300 ) mm ], forearm [right: 1.150 (1.200 ) mm vs.0.800 (0.275)mm;left:1.250 (0.850 ) mm vs.0.800 (0.300 ) mm],and foot dorsum [right:1.200 (0.925)mm vs.1.150(0.450)mm;left:0.800(0.900)mm vs.0.700(0.200)mm]was thicker in dcSSc patients than controls.The epidermal,dermal,and full skin thickness were higher in clinical Rodnan score 1,2,3 than controls.The dermal and full skin thickness was higher in score 1,2 than 0.The epidermal thickness was higher in score 2 than 0. Conclusion High frequency ultrasound measurement of skin thickness is feasible and reliable for assessing the skin involvement in dcSSc.