CAJ | 학술논문

G蛋白偶联受体（ GPCR ）超家族是数目最多并具有重要生理功能的一类受体，其功能紊乱与许多重大疾病的发生、发展密切相关。据统计，世界上约45％的临床药物直接靶向GPCR及其信号转导途径。当今，全球新药研发进入低谷，针对靶点的药物研发遇到瓶颈，如何有机整合GPCR领域的最新进展，有效衔接以GPCR为药靶的基础研究、临床研究和药物研发是该领域继续引领全球生物医药发展的关键。鉴于GPCR在重大疾病研究中的作用及发展前景，重大疾病导向的G蛋白偶联受体结构、功能和配体发现研究十分迫切。
G단백우련수체（ GPCR ）초가족시수목최다병구유중요생리공능적일류수체，기공능문란여허다중대질병적발생、발전밀절상관。거통계，세계상약45％적림상약물직접파향GPCR급기신호전도도경。당금，전구신약연발진입저곡，침대파점적약물연발우도병경，여하유궤정합GPCR영역적최신진전，유효함접이GPCR위약파적기출연구、림상연구화약물연발시해영역계속인령전구생물의약발전적관건。감우GPCR재중대질병연구중적작용급발전전경，중대질병도향적G단백우련수체결구、공능화배체발현연구십분박절。
G-protein coupled receptor ( GPCR) superfamily is the largest protein family within human genome and has various physiological roles.Dysfunction of these recep-tors often leads to significant human diseases.Up to date , there are about 45%of marketed drugs are direct-ly targeting on GPCRs or their pathways.The global drug discovery is currently hitting a bottleneck, and in-tegrating the basic research, clinical research and drug development targeting on GPCRs becomes more and more important.In the light of their roles and perspec-tives in the treatment of important human diseases, the structural and functional research, as well as ligand de-velopment based on GPCRs related to important human diseases is extremely urgent.