CAJ | 학술논문

人呼吸道合胞病毒(resipiratory syncytial virus,RSV)是世界范围内儿童下呼吸道感染的主要病原体,但其疫苗的开发面临许多困难和挑战.随着反向遗传学及相关技术和工具的应用,RSV疫苗,尤其是减毒活疫苗的研制已经取得很大进展.此文就RSV减毒活疫苗研发的主要突破和研究进展进行综述.
인호흡도합포병독(resipiratory syncytial virus,RSV)시세계범위내인동하호흡도감염적주요병원체,단기역묘적개발면림허다곤난화도전.수착반향유전학급상관기술화공구적응용,RSV역묘,우기시감독활역묘적연제이경취득흔대진전.차문취RSV감독활역묘연발적주요돌파화연구진전진행종술.
Human respiratory syncytial virus (RSV) is the main pathogen of lower respiratory tract infection of children around the world,but the development of the vaccine is facing many difficulties and challenges.With the application of reverse genetics and related technology,the development of RSV vaccine has made great progress,especially in live-attenuated vaccines development.In this paper,the major breakthrough and research progress of live-attenuated RSV vaccine development are reviewed.