CAJ | 학술논문

目的：系统评价氟伐他汀与辛伐他汀调脂作用的有效性及安全性。方法：采用循证医学的文献分析评价方法，计算机检索Cochrane图书馆、Pubmed、EMbase、中国生物医学文献光盘数据库、中国期刊全文数据库、维普中文科技期刊、万方数字化期刊群等数据库，全面收集氟伐他汀与辛伐他汀调脂作用的有效性和安全性的随机对照试验。评价纳入研究的方法学质量，提取有效数据，采用RevMan 5.1软件对数据进行Meta分析。结果：检索到辛伐他汀和氟伐他汀调脂作用的有效性及安全性的随机对照试验共16篇，其中中文文献11篇，英文文献5篇。辛伐他汀在降低TC及TG水平方面显著优于氟伐他汀，辛伐他汀在降低LDL水平及升高HDL水平方面也具有优势，经济学评价结果同样显示辛伐他汀具有优势，安全性评价结果显示两组治疗方案安全性相当。结论：辛伐他汀调脂疗效优于氟伐他汀，安全性与氟伐他汀相当，经济学方面具有明显优势。但由于纳入的研究数量有限，该系统评价的结果需谨慎对待，尚需更多的设计合理、多中心、大样本的RCT以进一步证实。
목적：계통평개불벌타정여신벌타정조지작용적유효성급안전성。방법：채용순증의학적문헌분석평개방법，계산궤검색Cochrane도서관、Pubmed、EMbase、중국생물의학문헌광반수거고、중국기간전문수거고、유보중문과기기간、만방수자화기간군등수거고，전면수집불벌타정여신벌타정조지작용적유효성화안전성적수궤대조시험。평개납입연구적방법학질량，제취유효수거，채용RevMan 5.1연건대수거진행Meta분석。결과：검색도신벌타정화불벌타정조지작용적유효성급안전성적수궤대조시험공16편，기중중문문헌11편，영문문헌5편。신벌타정재강저TC급TG수평방면현저우우불벌타정，신벌타정재강저LDL수평급승고HDL수평방면야구유우세，경제학평개결과동양현시신벌타정구유우세，안전성평개결과현시량조치료방안안전성상당。결론：신벌타정조지료효우우불벌타정，안전성여불벌타정상당，경제학방면구유명현우세。단유우납입적연구수량유한，해계통평개적결과수근신대대，상수경다적설계합리、다중심、대양본적RCT이진일보증실。
Objective: To evaluate the efficacy, safety and economics offluvastatin and simvastatin in the treatment of hypercholesterolemia.Methods: Literature analysis based on evidence-based medicine was performed. Computer retrieval was conducted to search for randomly controlled trials on the impact offluvastatin and simvastatin on anti- hypercholesterolemia efficacy, safety and economics. The quality of included studies was evaluated. Data were extracted into a specially designed extraction form. The Cochrane collaboration’s RevMan5.1 software was used for data analysis.Results: The meta-analysis of 16 included RCTs showed that simvastatin treatment was associated with significantly greater reductions in TC, TG and LDL and increases in HDL. Simvastatin has greater superiority in cost-effectiveness compared withfluvastatin.Conclusion: It has been demonstrated that simvastatin is more effective and economic in the treatment of hypercholesterolemia compared withfluvastatin. High-quality large-scale multiple-centered samples RCTs are required.