临床普外科电子杂志
臨床普外科電子雜誌
림상보외과전자잡지
Journal of General Surgery for Clinicians (Electronic Version)
2014年
4期
45-49
,共5页
白国立(综述)%史光军(审校)
白國立(綜述)%史光軍(審校)
백국립(종술)%사광군(심교)
脂肪间充质干细胞%PDX-1%胰岛分泌细胞%胰岛移植%糖尿病
脂肪間充質榦細胞%PDX-1%胰島分泌細胞%胰島移植%糖尿病
지방간충질간세포%PDX-1%이도분비세포%이도이식%당뇨병
Adipose mesenchymal stem cells%PDX-1%Islet secretion cells%Pancreatic islets transplantation%Diabetes
1型糖尿病主要是由于胰岛β细胞破坏导致胰岛素绝对缺乏引起，胰岛β细胞无法再生，也不能进行异种移植，干细胞移植是治疗糖尿病的新型方法。已有研究证实了脂肪间充质干细胞（adipose mesenchymal stem cells, ADSC）能够被诱导分化成胰岛素分泌细胞，也有研究显示了胰十二指肠同源盒基因-1（PDX-1）可诱导非胰岛分泌细胞如骨髓间充质干细胞、脂肪间充质干细胞等向胰岛素分泌细胞分化，提示PDX-1在改善胰岛β细胞再生和促进胰岛细胞恢复中有着巨大潜能。本文就当前 PDX-1基因提高脂肪间充质干细胞分化为胰岛分泌细胞能力的研究前景作一综述。
1型糖尿病主要是由于胰島β細胞破壞導緻胰島素絕對缺乏引起，胰島β細胞無法再生，也不能進行異種移植，榦細胞移植是治療糖尿病的新型方法。已有研究證實瞭脂肪間充質榦細胞（adipose mesenchymal stem cells, ADSC）能夠被誘導分化成胰島素分泌細胞，也有研究顯示瞭胰十二指腸同源盒基因-1（PDX-1）可誘導非胰島分泌細胞如骨髓間充質榦細胞、脂肪間充質榦細胞等嚮胰島素分泌細胞分化，提示PDX-1在改善胰島β細胞再生和促進胰島細胞恢複中有著巨大潛能。本文就噹前 PDX-1基因提高脂肪間充質榦細胞分化為胰島分泌細胞能力的研究前景作一綜述。
1형당뇨병주요시유우이도β세포파배도치이도소절대결핍인기，이도β세포무법재생，야불능진행이충이식，간세포이식시치료당뇨병적신형방법。이유연구증실료지방간충질간세포（adipose mesenchymal stem cells, ADSC）능구피유도분화성이도소분비세포，야유연구현시료이십이지장동원합기인-1（PDX-1）가유도비이도분비세포여골수간충질간세포、지방간충질간세포등향이도소분비세포분화，제시PDX-1재개선이도β세포재생화촉진이도세포회복중유착거대잠능。본문취당전 PDX-1기인제고지방간충질간세포분화위이도분비세포능력적연구전경작일종술。
Type 1 diabetes mellitus is mainly caused by destruction of pancreatic isletβ cells leading to an absolute lack of insulin. Neither pancreatic isletβ cells can regenerate, nor for xenotransplantation. And stem cell transplantation is a new type of method in the treatment of diabetes mellitus. Studies have been confirmed that the adipose mesenchymal stem cells (ADSC) can be induced to differentiate into insulin-producing cells. In addition, there is also a study showed that pancreatic and duodenal homeobox factor-1(PDX-1) can induce the non-insulin secretion cells such as bone marrow mesenchymal stem cells, adipose mesenchymal stem cells into islet secretion cells differentiation, prompt that PDX-1 in improving isletβ cells and recovering has huge potential. In this paper, we report the research prospects of the current PDX-1 gene can improve adipose mesenchymal stem cells to differentiate into islet secretion cells ability.
