CAJ | 학술논문

目的：探讨血液透析滤过联合血液透析治疗尿毒症顽固性皮肤瘙痒的临床效果及机制。方法选择40例尿毒症并伴有顽固性皮肤瘙痒的维持性血液透析患者，运用血液透析滤过方法观察治疗前后PTH、β2-MG数值变化以及患者皮肤瘙痒缓解情况。结果治疗后患者的PTH、β2-MG降低，瘙痒症状明显减轻（ P<0.05）。结论血液透析滤过能有效清除PTH、β2-MG大中分子物质，是治疗尿毒症患者皮肤瘙痒的有效方法。
목적：탐토혈액투석려과연합혈액투석치료뇨독증완고성피부소양적림상효과급궤제。방법선택40례뇨독증병반유완고성피부소양적유지성혈액투석환자，운용혈액투석려과방법관찰치료전후PTH、β2-MG수치변화이급환자피부소양완해정황。결과치료후환자적PTH、β2-MG강저，소양증상명현감경（ P<0.05）。결론혈액투석려과능유효청제PTH、β2-MG대중분자물질，시치료뇨독증환자피부소양적유효방법。
Objective:To observe the effect and mechanism of Hemodiafiltration( HDF)in treating obstinate uremic pruritus. Methods:All of 40 cases with the symptoms of obstinate uremia pruritus were treated by means of HDF. Results:HDF effectively eliminated PTH and β2-MG,and alleviated the sKin pruritus(P<0. 05). Conclusion:HDF can not only improve the sKin itch symptom of uremia patients,but also decrease the levels of PTH andβ2-MG in serum as well,which is effective for patients with uremic and has great value in clinical application.