CAJ | 학술논문

目的：探讨奥沙利铂在临床应用中的不良反应。方法收集2009年3月至2014年3月就诊于西安交通大学第一医院、第二医院及解放军323医院2517例胃肠道肿瘤患者中以奥沙利铂为主要化疗方案的临床资料，回顾性分析139例奥沙利铂不良反应的发生情况及临床特征。结果2517例患者中奥沙利铂不良反应139例，发生率为5.52%（139/2517）；不良反应主要为消化系统毒性、神经系统毒性、造血系统毒性、骨髓抑制、过敏反应和药物热等，以消化道不良反应所占比例最高，达54.82%，发生的不良反应程度轻，经积极处理均可治愈或好转。奥沙利铂药物引发的不良反应与性别、年龄、原发肿瘤类型以及化疗方案无统计学差异（ P>0.05）。结论奥沙利铂药物引发的不良反应程度轻，与性别、年龄、原发肿瘤类型以及化疗方案无明显相关，积极预防和处理均可治愈或好转，因此在应用奥沙利铂化疗时要密切监测不良反应，及时做好不良反应的预防和处理。
목적：탐토오사리박재림상응용중적불량반응。방법수집2009년3월지2014년3월취진우서안교통대학제일의원、제이의원급해방군323의원2517례위장도종류환자중이오사리박위주요화료방안적림상자료，회고성분석139례오사리박불량반응적발생정황급림상특정。결과2517례환자중오사리박불량반응139례，발생솔위5.52%（139/2517）；불량반응주요위소화계통독성、신경계통독성、조혈계통독성、골수억제、과민반응화약물열등，이소화도불량반응소점비례최고，체54.82%，발생적불량반응정도경，경적겁처리균가치유혹호전。오사리박약물인발적불량반응여성별、년령、원발종류류형이급화료방안무통계학차이（ P>0.05）。결론오사리박약물인발적불량반응정도경，여성별、년령、원발종류류형이급화료방안무명현상관，적겁예방화처리균가치유혹호전，인차재응용오사리박화료시요밀절감측불량반응，급시주호불량반응적예방화처리。
Objective:To explore the adverse reactions of oxaliplatin in clinical application. Methods:2517 cases of pa-tients with gastrointestinal cancer therapy with oxaliplatin From March 2009 to March 2014 were used as the main clinical data,and the occurrence and clinical characteristics of the retrospective analysis of 139 cases of adverse reactions of oxali-platin were made. Results:In 2517 cases,139 cases of patients had adverse reactions of oxaliplatin with the incidence rate at 5. 52%( 139/2517 );adverse reactions included gastrointestinal toxicity,neurotoxicity,hematopoietic toxicity,bone marrow suppression,allergic reactions and drug fever,with adverse reaction of close digestive tract being the most high,up to 54. 82%,the degree of adverse reaction was light,and adverse reaction was cured or improved after active treatment;there was no statistical difference in oxaliplatin induced by drug adverse reaction and sex,age,type of primary tumor and chemotherapy(P>0. 05). Conclusion:It is important to monitor adverse reactions in the application of oxaliplatin chemo-therapy,so that prevention and treatment are done in a timely manner for adverse reaction.