泰山医学院学报
泰山醫學院學報
태산의학원학보
JOURNAL OF TAISHAN MEDICAL COLLEGE
2015年
5期
490-493
,共4页
VDR基因多态性%25羟基维生素D3%糖尿病视网膜病变
VDR基因多態性%25羥基維生素D3%糖尿病視網膜病變
VDR기인다태성%25간기유생소D3%당뇨병시망막병변
Vitamin D receptor gene FoKI polymorphism%serum 25-dihydroxyvitamin D%diabetic retinopathy
目的:探讨维生素D受体( VDR)基因FoKI多态性与糖尿病视网膜病变( DR)的关系。方法按1999年WHO 糖尿病( DM )诊断及分型标准,选取无亲缘关系的汉族2型糖尿病患者254例,分为单纯2型糖尿病( DM)组、非增殖性视网膜病变( NPDR)组、增殖性视网膜病变( PDR)组,选取健康人群120例为对照组( NC)。采用PCR-RFLP方法确定受试者的VDR基因FoKI基因型,对不同组间的临床与生化指标及VDR基因FoKI多态性进行统计分析。结果 NPDR组和PDR组的 ff 基因型频率显著高于 DM 组(χ2=7.49,4.448,P<0.05),NPDR组和PDR组的f等位基因频率显著高于DM组(χ2=8.333,5.227,P<0.05);NPDR组和PDR组的ff基因型频率显著高于NC组(χ2=9.934,4.899,P<0.05);,NPDR组和PDR组的f等位基因频率显著高于NC组(χ2=10.895,5.714,P<0.05),而 NPDR和 PDR组(Ff + FF)基因型频率显著低于 NC组(χ2=9.934,10.895,P<0.05)、NP-DR 和 PDR组F等位基因频率显著低于 NC组(χ2=4.899,5.714,P<0.05);NPDR和 PDR组( Ff + FF)基因型频率显著低于DM组(χ2=7.490,8.333,P<0.01;NPDR和PDR组F等位基因频率显著低于DM组(χ2=4.448,χ2=5.227,P<0.05);DR的多重危险因素分析示低密度脂蛋白胆固醇( LDL-C)、总胆固醇( TC)和糖化血红蛋白(HbA1c)与DR的患病率呈正相关,而 VDR 基因 FoKI 多态性与 DR 发病危险呈负相关(β=-1.027,OR =0.343,P<0.01,CI:0.157~0.723)。结论中国汉族人群中存在VDR基因FoKI多态性,f基因可能是中国汉族糖尿病患者易于发生DR的危险遗传性标志。
目的:探討維生素D受體( VDR)基因FoKI多態性與糖尿病視網膜病變( DR)的關繫。方法按1999年WHO 糖尿病( DM )診斷及分型標準,選取無親緣關繫的漢族2型糖尿病患者254例,分為單純2型糖尿病( DM)組、非增殖性視網膜病變( NPDR)組、增殖性視網膜病變( PDR)組,選取健康人群120例為對照組( NC)。採用PCR-RFLP方法確定受試者的VDR基因FoKI基因型,對不同組間的臨床與生化指標及VDR基因FoKI多態性進行統計分析。結果 NPDR組和PDR組的 ff 基因型頻率顯著高于 DM 組(χ2=7.49,4.448,P<0.05),NPDR組和PDR組的f等位基因頻率顯著高于DM組(χ2=8.333,5.227,P<0.05);NPDR組和PDR組的ff基因型頻率顯著高于NC組(χ2=9.934,4.899,P<0.05);,NPDR組和PDR組的f等位基因頻率顯著高于NC組(χ2=10.895,5.714,P<0.05),而 NPDR和 PDR組(Ff + FF)基因型頻率顯著低于 NC組(χ2=9.934,10.895,P<0.05)、NP-DR 和 PDR組F等位基因頻率顯著低于 NC組(χ2=4.899,5.714,P<0.05);NPDR和 PDR組( Ff + FF)基因型頻率顯著低于DM組(χ2=7.490,8.333,P<0.01;NPDR和PDR組F等位基因頻率顯著低于DM組(χ2=4.448,χ2=5.227,P<0.05);DR的多重危險因素分析示低密度脂蛋白膽固醇( LDL-C)、總膽固醇( TC)和糖化血紅蛋白(HbA1c)與DR的患病率呈正相關,而 VDR 基因 FoKI 多態性與 DR 髮病危險呈負相關(β=-1.027,OR =0.343,P<0.01,CI:0.157~0.723)。結論中國漢族人群中存在VDR基因FoKI多態性,f基因可能是中國漢族糖尿病患者易于髮生DR的危險遺傳性標誌。
목적:탐토유생소D수체( VDR)기인FoKI다태성여당뇨병시망막병변( DR)적관계。방법안1999년WHO 당뇨병( DM )진단급분형표준,선취무친연관계적한족2형당뇨병환자254례,분위단순2형당뇨병( DM)조、비증식성시망막병변( NPDR)조、증식성시망막병변( PDR)조,선취건강인군120례위대조조( NC)。채용PCR-RFLP방법학정수시자적VDR기인FoKI기인형,대불동조간적림상여생화지표급VDR기인FoKI다태성진행통계분석。결과 NPDR조화PDR조적 ff 기인형빈솔현저고우 DM 조(χ2=7.49,4.448,P<0.05),NPDR조화PDR조적f등위기인빈솔현저고우DM조(χ2=8.333,5.227,P<0.05);NPDR조화PDR조적ff기인형빈솔현저고우NC조(χ2=9.934,4.899,P<0.05);,NPDR조화PDR조적f등위기인빈솔현저고우NC조(χ2=10.895,5.714,P<0.05),이 NPDR화 PDR조(Ff + FF)기인형빈솔현저저우 NC조(χ2=9.934,10.895,P<0.05)、NP-DR 화 PDR조F등위기인빈솔현저저우 NC조(χ2=4.899,5.714,P<0.05);NPDR화 PDR조( Ff + FF)기인형빈솔현저저우DM조(χ2=7.490,8.333,P<0.01;NPDR화PDR조F등위기인빈솔현저저우DM조(χ2=4.448,χ2=5.227,P<0.05);DR적다중위험인소분석시저밀도지단백담고순( LDL-C)、총담고순( TC)화당화혈홍단백(HbA1c)여DR적환병솔정정상관,이 VDR 기인 FoKI 다태성여 DR 발병위험정부상관(β=-1.027,OR =0.343,P<0.01,CI:0.157~0.723)。결론중국한족인군중존재VDR기인FoKI다태성,f기인가능시중국한족당뇨병환자역우발생DR적위험유전성표지。
Objective:To study the Vitamin D receptor gene FoKI polymorphism in Chinese Han population and to ana-lyze the relationship between the polymorphism and diabetic retinopathy( DR). Methods:Two hundred and fifty four pa-tients with type 2 diabetes mellitus recruited in this study were divided into NPDR group( non-proliferative diabetic reti-nopathy),PDR group( proliferative diabetic retinopathy)and DM( diabetes without retinopathy)group. The normal con-trol group consisted of 120 subjects. Genotypes were identified by PCR-RFLP among all the subjects,while other clinical parameters were measured. Serum levels of 25-( OH)VD3 were tested by the method of ELISA. Results:The frequencies of both genotype ff and allele f were significantly higher in the NPDR group and the PDR group than those in the NC group (χ2 = 9. 934,4. 899,P<0. 05;χ2 =10. 895,5. 714,P<0. 05)and the DM group(χ2 = 7. 49,4. 448,P<0. 05;χ2 =8. 333,5. 227,P<0. 05). However,the frequencies of genotype(Ff + FF)and allele F were significantly lower in the NPDR group and the PDR(χ2 =7. 490,8. 333,P<0. 01 and χ2 =4. 448,5. 227,P<0. 05). Multivariate logistic regression analy-sis showed that the levels of glycohemoglobin(HbA1c),total cholesterol,low-density lipoprotein cholesterol presented a positive correlation with DR respectively,and the Vitamin D Receptor Gene FoKI Polymorphism exhibited a negative correla-tion with DR(β= -1. 027,OR=0. 343,P<0. 01,CI:0. 157~0. 723). Conclusion:There is the presence of the VDR gene FoKI polymorphism in the Han population in China,while allele f may be a protective genetic marKer of DR.