中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
438-439,446
,共3页
复发性流产%胰岛素抵抗%Meta分析%相关性
複髮性流產%胰島素牴抗%Meta分析%相關性
복발성유산%이도소저항%Meta분석%상관성
recurrent spontaneous abortion ( RSA)%insulin resistance ( IR)%Meta-analysis%correlation
目的：对国内外发表的随机病例对照研究文章进行Meta分析,力图探明胰岛素抵抗( IR)是否增加孕产妇复发性流产( RSA)的风险。方法使用计算机检索PubMed、Embase、Springer Link、中国生物医学文献数据库等数据库及手工检索相关期刊内自1996年1月至2014年1月之间发表的有关于RSA与IR关系的病例对照研究类国内外文献,按既定标准筛选后对入组文献进行质量评分,并使用Meta分析探究两者间关系。结果分析中共计6篇国内外文献选入研究范围,RSA组共计432例孕产妇,对照组共计383例(均未见不良孕产史)。分析提示,两组孕产妇在空腹血糖水平差异无统计学意义的前提下,出现了RSA组患者空腹胰岛素数值相对升高及RSA组患者的胰岛β细胞功能受损较对照组严重；且RSA组患者的IR指数较对照组高,即IR指数>4.5的患者大多来自RSA组,差异具有统计学意义(OR=3.16,95%CI为1.7~6.8,I2=1.157,P<0.05)。结论 IR与RSA间存在一定相关性,其可能为RSA的原因之一。
目的：對國內外髮錶的隨機病例對照研究文章進行Meta分析,力圖探明胰島素牴抗( IR)是否增加孕產婦複髮性流產( RSA)的風險。方法使用計算機檢索PubMed、Embase、Springer Link、中國生物醫學文獻數據庫等數據庫及手工檢索相關期刊內自1996年1月至2014年1月之間髮錶的有關于RSA與IR關繫的病例對照研究類國內外文獻,按既定標準篩選後對入組文獻進行質量評分,併使用Meta分析探究兩者間關繫。結果分析中共計6篇國內外文獻選入研究範圍,RSA組共計432例孕產婦,對照組共計383例(均未見不良孕產史)。分析提示,兩組孕產婦在空腹血糖水平差異無統計學意義的前提下,齣現瞭RSA組患者空腹胰島素數值相對升高及RSA組患者的胰島β細胞功能受損較對照組嚴重；且RSA組患者的IR指數較對照組高,即IR指數>4.5的患者大多來自RSA組,差異具有統計學意義(OR=3.16,95%CI為1.7~6.8,I2=1.157,P<0.05)。結論 IR與RSA間存在一定相關性,其可能為RSA的原因之一。
목적：대국내외발표적수궤병례대조연구문장진행Meta분석,력도탐명이도소저항( IR)시부증가잉산부복발성유산( RSA)적풍험。방법사용계산궤검색PubMed、Embase、Springer Link、중국생물의학문헌수거고등수거고급수공검색상관기간내자1996년1월지2014년1월지간발표적유관우RSA여IR관계적병례대조연구류국내외문헌,안기정표준사선후대입조문헌진행질량평분,병사용Meta분석탐구량자간관계。결과분석중공계6편국내외문헌선입연구범위,RSA조공계432례잉산부,대조조공계383례(균미견불량잉산사)。분석제시,량조잉산부재공복혈당수평차이무통계학의의적전제하,출현료RSA조환자공복이도소수치상대승고급RSA조환자적이도β세포공능수손교대조조엄중；차RSA조환자적IR지수교대조조고,즉IR지수>4.5적환자대다래자RSA조,차이구유통계학의의(OR=3.16,95%CI위1.7~6.8,I2=1.157,P<0.05)。결론 IR여RSA간존재일정상관성,기가능위RSA적원인지일。
Objective To explore whether insulin resistance (IR) increases maternal recurrent spontaneous abortion (RSA) by meta-analysis of published articles at home and abroad with randomized case-control study. Methods Literatures on case-control study on relationship between RSA and IR published during the period of January 1996 to January 2014 were retrieved in PubMed, Embase, Springer link, Chinese Biomedical Literature Database with computer and other journals by hand, and they were screened with set standard and grouped for analysis. Meta-analysis was conducted for the relationship between them. Results Totally 6 articles were selected into the study. There were 432 pregnant women in RSA group and 383 cases in control group ( no abnormal pregnancy history was found) . Under the condition of no significant difference in fasting glucose level, fasting insulin value elevated and isletβ-cell function was impaired more severely in RSA group. IR index was higher in RSA group, which suggested that most of cases with IR index higher than 4. 5 were from RSA group, and the difference was significant (OR=3. 16, 95%CI:1. 7-6. 8,I2 =1. 157,P<0. 05). Conclusion IR is correlated with RSA among pregnant women, and it might be one cause of RSA.
