中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
592-594
,共3页
超敏C反应蛋白%同型半胱氨酸%妊娠期糖尿病%空腹血糖%胰岛素
超敏C反應蛋白%同型半胱氨痠%妊娠期糖尿病%空腹血糖%胰島素
초민C반응단백%동형반광안산%임신기당뇨병%공복혈당%이도소
high sensitivity C-reactive protein ( hs-CRP )%homocysteine ( Hcy )%gestational diabetes mellitus ( GDM )%fasting plasma glucose ( FPG)%insulin
目的：探讨联合检测超敏C反应蛋白( hs-CRP)和同型半胱氨酸( Hcy)水平在妊娠期糖尿病( GDM)诊断及对妊娠结局的预测价值。方法选择2012年1月至2014年3月在安吉县第三人民医院门诊接受检查的GDM患者35例作为观察组；选择同期经临床排除GDM的正常孕产妇35例作为对照组。检测两组患者的hs-CRP和Hcy、空腹血糖和胰岛素水平,并跟踪两组妊娠结局。结果观察组患者空腹血糖、胰岛素、hs-CRP 和 Hcy 水平均高于对照组,均有显著性差异( t 值分别为13.07、12.02、3.65和12.02,均P<0.05)；观察组不良反应发生率为34.3%(12/35),对照组为11.4%(4/35),具有显著性差异(χ2=5.19,P<0.05)。有16例发生不良妊娠结局,其与54例正常妊娠者的hs-CRP和Hcy水平比较均明显增高,并有显著性差异( t值分别为7.88、14.17,均P<0.05)。结论妊娠女性的hs-CRP和Hcy水平与GDM发生具有密切联系,且高水平hs-CRP和Hcy对不良妊娠结局具有一定的预测作用,应该引起产科注意。
目的：探討聯閤檢測超敏C反應蛋白( hs-CRP)和同型半胱氨痠( Hcy)水平在妊娠期糖尿病( GDM)診斷及對妊娠結跼的預測價值。方法選擇2012年1月至2014年3月在安吉縣第三人民醫院門診接受檢查的GDM患者35例作為觀察組；選擇同期經臨床排除GDM的正常孕產婦35例作為對照組。檢測兩組患者的hs-CRP和Hcy、空腹血糖和胰島素水平,併跟蹤兩組妊娠結跼。結果觀察組患者空腹血糖、胰島素、hs-CRP 和 Hcy 水平均高于對照組,均有顯著性差異( t 值分彆為13.07、12.02、3.65和12.02,均P<0.05)；觀察組不良反應髮生率為34.3%(12/35),對照組為11.4%(4/35),具有顯著性差異(χ2=5.19,P<0.05)。有16例髮生不良妊娠結跼,其與54例正常妊娠者的hs-CRP和Hcy水平比較均明顯增高,併有顯著性差異( t值分彆為7.88、14.17,均P<0.05)。結論妊娠女性的hs-CRP和Hcy水平與GDM髮生具有密切聯繫,且高水平hs-CRP和Hcy對不良妊娠結跼具有一定的預測作用,應該引起產科註意。
목적：탐토연합검측초민C반응단백( hs-CRP)화동형반광안산( Hcy)수평재임신기당뇨병( GDM)진단급대임신결국적예측개치。방법선택2012년1월지2014년3월재안길현제삼인민의원문진접수검사적GDM환자35례작위관찰조；선택동기경림상배제GDM적정상잉산부35례작위대조조。검측량조환자적hs-CRP화Hcy、공복혈당화이도소수평,병근종량조임신결국。결과관찰조환자공복혈당、이도소、hs-CRP 화 Hcy 수평균고우대조조,균유현저성차이( t 치분별위13.07、12.02、3.65화12.02,균P<0.05)；관찰조불량반응발생솔위34.3%(12/35),대조조위11.4%(4/35),구유현저성차이(χ2=5.19,P<0.05)。유16례발생불량임신결국,기여54례정상임신자적hs-CRP화Hcy수평비교균명현증고,병유현저성차이( t치분별위7.88、14.17,균P<0.05)。결론임신녀성적hs-CRP화Hcy수평여GDM발생구유밀절련계,차고수평hs-CRP화Hcy대불량임신결국구유일정적예측작용,응해인기산과주의。
Objective To evaluate the value of combined detection of high sensitivity C-reactive protein ( hs-CRP ) and homocysteine (Hcy) levels in diagnosing gestational diabetes mellitus (GDM) and its value on predicting pregnancy outcomes. Methods Thirty-five women with GDM accepting pre-natal screening in Third People’ s Hospital of Anji County from January 2012 to March 2014 were selected in observation group. Another 35 healthy women diagnosed without GDM at the same period were selected in control group. The levels of hs-CRP, Hcy, fasting plasma glucose ( FPG) and fasting insulin ( FINS) in two groups were detected and compared, and the pregnancy outcomes were followed up. Results The levels of FPG, FINS, hs-CRP and Hcy in the observation group were higher than those in the control group, and the differences were significant (t value was 13. 07, 12. 02, 3. 65 and 12. 02, respectively, all P <0. 05). The incidence of adverse reactions was 34. 3% (12/35) and 11. 4% (4/35) in the observation group and the control group, respectively with statistical significance (χ2 =5. 19,P<0. 05). Sixteen cases were found with adverse pregnancy outcomes, and their hs-CRP and Hcy levels were higher than those of 54 normal pregnant women (t value was 7. 88 and 14. 17, respectively, both P<0. 05). Conclusion The levels of hs-CRP and Hcy are closely related with GDM, and the high levels have predictive value for adverse pregnancy outcomes. Therefore, attention should be attracted on them.
