CAJ | 학술논문

目的：探索妊娠期高血压疾病患者( PIH)的外周血CD4+T细胞凋亡率及其对眼底病变的影响。方法选取2012年1月至2014年1月鄞州人民医院产科接收的68例妊娠期高血压疾病患者作为PIH组(眼底病变组),而同期接收的38例正常分娩产妇作为对照组(无眼底病变组),检测并分析产前和产后外周静脉血 CD4+T细胞凋亡率,并分析对眼底病变的影响。结果产前各组CD4+T细胞凋亡率比较有显著性差异(F=7.335,P<0.05)。产前PIH组CD4+T细胞凋亡率较对照组显著增加(t=5.192,P<0.05)。产前PIH 轻度组CD4+T细胞凋亡率较PIH中度、重度组显著增加(t值分别为8.554、7.783,均P<0.05)。产后各组CD4+T细胞凋亡率比较差异无显著性差异(F=2.934,P>0.05)。不同眼底病变程度患者产前和产后CD4+T细胞凋亡率比较均无显著性差异(F值分别为1.433、2.041,均P>0.05),产前和产后眼底病变分级与PIH程度均呈显著正相关(r值分别为0.577、0.639,均P<0.05)。结论妊娠期高血压疾病患者的眼底病变随患者临床病情的加重而呈加重的趋势,且产后较产前普遍好转,外周血CD4+T细胞凋亡对PIH的发生及病情发展具有一定的预警作用,但外周血CD4+T细胞凋亡在PIH患者视网膜病变的发生、发展中的作用有待进一步研究。
목적：탐색임신기고혈압질병환자( PIH)적외주혈CD4+T세포조망솔급기대안저병변적영향。방법선취2012년1월지2014년1월은주인민의원산과접수적68례임신기고혈압질병환자작위PIH조(안저병변조),이동기접수적38례정상분면산부작위대조조(무안저병변조),검측병분석산전화산후외주정맥혈 CD4+T세포조망솔,병분석대안저병변적영향。결과산전각조CD4+T세포조망솔비교유현저성차이(F=7.335,P<0.05)。산전PIH조CD4+T세포조망솔교대조조현저증가(t=5.192,P<0.05)。산전PIH 경도조CD4+T세포조망솔교PIH중도、중도조현저증가(t치분별위8.554、7.783,균P<0.05)。산후각조CD4+T세포조망솔비교차이무현저성차이(F=2.934,P>0.05)。불동안저병변정도환자산전화산후CD4+T세포조망솔비교균무현저성차이(F치분별위1.433、2.041,균P>0.05),산전화산후안저병변분급여PIH정도균정현저정상관(r치분별위0.577、0.639,균P<0.05)。결론임신기고혈압질병환자적안저병변수환자림상병정적가중이정가중적추세,차산후교산전보편호전,외주혈CD4+T세포조망대PIH적발생급병정발전구유일정적예경작용,단외주혈CD4+T세포조망재PIH환자시망막병변적발생、발전중적작용유대진일보연구。
Objective To explore the apoptosis rate of CD4 + T cell in peripheral blood and its effect on retinopathy in patients with pregnancy induced hypertension ( PIH) . Methods From January 2012 to January 2014 68 inpatiants with PIH in obstetric department of Yinzhou People’s Hospital were collected as PIH group (retinopathy group), and 38 pregnant women with normal delivery at the same period were recruited in control group (non-retinopathy group). The prenatal and postnatal apoptosis rates of CD4 +T cell in peripheral blood were detected, and the influences on retinopathy were analyzed. Results Prenatal apoptosis rate of CD4 +T cell was significantly different among different groups (F=7.335, P<0. 05), and it was higher in PIH groups than in the control group (t=5. 192, P<0. 05). Prenatal CD4 +T cell apoptosis rate of mild PIH group was significantly increased than that of moderate PIH group and severe PIH group (t value was 8. 554 and 7. 783, respectively, both P <0. 05). Postnatal CD4 + T cell apoptosis rate of all groups was not significantly different (F=2. 934, P>0. 05). Prenatal and postnatal CD4 +T cell apoptosis rate showed no obvious difference between patients with different degree of retinopathy (F value was 1. 433 and 2. 041, respectively, both P>0. 05), and prenatal and postnatal retinopathy grade were positively correlated with the extent of PIH degree (r value was 0. 577 and 0. 639, respectively, both P<0. 05). Conclusion The degree of retinopathy in PIH patients shows the same tendency with the degree of clinical symptoms, and the disease is improved after delivery. Peripheral blood CD4 +T cell apoptosis has a certain role in early warning for occurrence and progression of PIH. However, further studies are needed to explore the role of CD4 +T cell apoptosis in peripheral blood in the genesis and development of retinopathy in PIH patients.