中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
564-566
,共3页
上呼吸道病毒感染%利巴韦林气雾剂%小儿%疗效
上呼吸道病毒感染%利巴韋林氣霧劑%小兒%療效
상호흡도병독감염%리파위림기무제%소인%료효
upper respiratory tract viral infection%ribavirin aerosol%infant%therapeutic efficacy
目的：观察分析利巴韦林气雾剂与利巴韦林颗粒治疗小儿上呼吸道病毒性感染的疗效。方法选取2011年1月至2014年2月期间杭州市萧山区第一人民医院儿科收治的上呼吸道病毒性感染患儿120例,根据治疗方法不同分为接受利巴韦林气雾剂治疗的观察组和接受利巴韦林颗粒治疗的对照组,比较两组治疗效果、退热效果、感冒症状改善及不良反应。结果用药72h内,观察组治疗有效率高于对照组(χ2=3.927,P<0.05)；观察组用药48h、72h内体温恢复正常率均高于对照组(χ2值分别为4.302和8.711,均P<0.05)；治疗后12h,观察组咳嗽、流涕改善率高于对照组(χ2值分别为4.615和3.840,均P<0.05)；治疗72h,观察组咳嗽、流涕、全身不适症状改善率均高于对照组(χ2值分别为10.909、18.033、9.090,均P<0.05)；两组治疗期间不良反应发生率比较差异无统计学意义(χ2=1.405,P>0.05)。结论利巴韦林气雾剂起效迅速,有助于控制患儿临床症状,提高治疗效果。
目的：觀察分析利巴韋林氣霧劑與利巴韋林顆粒治療小兒上呼吸道病毒性感染的療效。方法選取2011年1月至2014年2月期間杭州市蕭山區第一人民醫院兒科收治的上呼吸道病毒性感染患兒120例,根據治療方法不同分為接受利巴韋林氣霧劑治療的觀察組和接受利巴韋林顆粒治療的對照組,比較兩組治療效果、退熱效果、感冒癥狀改善及不良反應。結果用藥72h內,觀察組治療有效率高于對照組(χ2=3.927,P<0.05)；觀察組用藥48h、72h內體溫恢複正常率均高于對照組(χ2值分彆為4.302和8.711,均P<0.05)；治療後12h,觀察組咳嗽、流涕改善率高于對照組(χ2值分彆為4.615和3.840,均P<0.05)；治療72h,觀察組咳嗽、流涕、全身不適癥狀改善率均高于對照組(χ2值分彆為10.909、18.033、9.090,均P<0.05)；兩組治療期間不良反應髮生率比較差異無統計學意義(χ2=1.405,P>0.05)。結論利巴韋林氣霧劑起效迅速,有助于控製患兒臨床癥狀,提高治療效果。
목적：관찰분석리파위림기무제여리파위림과립치료소인상호흡도병독성감염적료효。방법선취2011년1월지2014년2월기간항주시소산구제일인민의원인과수치적상호흡도병독성감염환인120례,근거치료방법불동분위접수리파위림기무제치료적관찰조화접수리파위림과립치료적대조조,비교량조치료효과、퇴열효과、감모증상개선급불량반응。결과용약72h내,관찰조치료유효솔고우대조조(χ2=3.927,P<0.05)；관찰조용약48h、72h내체온회복정상솔균고우대조조(χ2치분별위4.302화8.711,균P<0.05)；치료후12h,관찰조해수、류체개선솔고우대조조(χ2치분별위4.615화3.840,균P<0.05)；치료72h,관찰조해수、류체、전신불괄증상개선솔균고우대조조(χ2치분별위10.909、18.033、9.090,균P<0.05)；량조치료기간불량반응발생솔비교차이무통계학의의(χ2=1.405,P>0.05)。결론리파위림기무제기효신속,유조우공제환인림상증상,제고치료효과。
Objective To observe the therapeutic effect of ribavirin aerosol and ribavirin granules on treatment of pediatric viral upper respiratory tract infection. Methods From January 2011 to February 2014, 120 cases with pediatric upper respiratory tract viral infection in First People’ s Hospital in Xiaoshan District were enrolled and divided into observation group given ribavirin aerosol and control group given ribavirin granule. Treatment effect, antifebrile effect, cold symptoms improvement and adverse reaction were compared between two groups. Results Compared with the control group, the efficacy rate of the observation group was higher within 72 hours after treatment (χ2 =3. 927,P<0. 05), and within 48h and 72h the rate of body temperature coming to normal was significantly higher in the observation group (χ2 value was 4. 302 and 8. 711, respectively, both P<0. 05). Twelve hours after treatment, cough and runny nose improvement rate in the observation group was obviously higher (χ2 value was 4. 615 and 3. 840, respectively, both P <0. 05). After 72h, the improvement rates of cough, runny nose and systemic symptoms were significantly higher in the observation group than the control group (χ2 value was 10. 909, 18. 033 and 9. 090, respectively, all P<0. 05). There was no significant difference in adverse reactions between two groups (χ2 =1. 405,P >0. 05). Conclusion Ribavirin aerosol works more quickly, and it is helpful to control clinical symptoms and improve therapeutic efficacy.
