CAJ | 학술논문

目的：探讨布拉氏酵母菌( SB)对儿童抗生素相关性腹泻( AAD)的预防作用。方法将2014年1月至12月来自陕西省安康市石泉县医院儿科住院诊治为支气管炎和肺炎的患儿180例,随机分为观察组(90例)和对照组(90例),两组均给予静脉抗生素应用及对症支持治疗,观察组在开始使用抗生素时即口服布拉氏酵母菌散剂,对照组未予以布拉氏酵母菌散剂。比较两组患儿AAD发生率、大便次数及腹泻持续时间。结果观察组21例(23.3%)发生AAD,对照组30例(33.3%)发生AAD,两组患儿AAD发生率差异有统计学意义(χ2=4.078,P<0.05)；治疗组AAD患儿腹泻持续时间(3.19±0.68)d,对照组AAD患儿腹泻持续时间(5.24±0.79)d,两组比较差异有统计学意义(t=-10.115,P<0.05)。结论布拉氏酵母菌不仅能有效预防AAD的发生率,而且能够缩短婴幼儿AAD的腹泻持续时间。
목적：탐토포랍씨효모균( SB)대인동항생소상관성복사( AAD)적예방작용。방법장2014년1월지12월래자합서성안강시석천현의원인과주원진치위지기관염화폐염적환인180례,수궤분위관찰조(90례)화대조조(90례),량조균급여정맥항생소응용급대증지지치료,관찰조재개시사용항생소시즉구복포랍씨효모균산제,대조조미여이포랍씨효모균산제。비교량조환인AAD발생솔、대편차수급복사지속시간。결과관찰조21례(23.3%)발생AAD,대조조30례(33.3%)발생AAD,량조환인AAD발생솔차이유통계학의의(χ2=4.078,P<0.05)；치료조AAD환인복사지속시간(3.19±0.68)d,대조조AAD환인복사지속시간(5.24±0.79)d,량조비교차이유통계학의의(t=-10.115,P<0.05)。결론포랍씨효모균불부능유효예방AAD적발생솔,이차능구축단영유인AAD적복사지속시간。
Objective To explore the prevention of antibiotic associated diarrhea (AAD) by Saccharomyces boulardii (SB) in infants. Methods There were 180 cases of bronchitis and pneumonia from pediatrics department of Hospital of Shiquan Country in the period of January to December in 2014. They were randomly divided into treatment group (90 cases) and control group (90 cases) with intravenous antibiotics and support therapy. The treatment group was given oral SB at the beginning of antibiotics use, while the control group did not take SB. Two groups were compared in terms of the incidence of AAD,defecate frequency and duration of diarrhea. Results There were 21 cases (23. 3%) and 30 cases (33. 3%) suffering AAD in the treatment group and the control group, respectively, and the difference in AAD incidence was significant (χ2 =4. 078,P<0. 05). The duration of AAD was 3. 19 ± 0. 68d in the treatment group and 5. 24 ± 0. 79d in the control group with significant difference between two groups (t= -10. 115,P<0. 05). Conclusion BS can prevent AAD in infants effectively, and it also can shorten the duration of AAD.