CAJ | 학술논문

伪石榴碱是一种重要的生物碱，存在于石榴的茎皮、根皮和果皮中。伪石榴碱具有一个独特的9-氮杂双环[3.3.1]壬烷结构，该结构与托品酮类似，是一些活性物质的主要骨架。本文综述伪石榴碱的提取、合成方法及其衍生物在生物活性和合成方面的应用，指出研究伪石榴碱的提取和生物活性、进一步合成更加新颖的伪石榴碱衍生物并研究其应用是研究伪石榴碱及其衍生物下一步需要解决的问题。
위석류감시일충중요적생물감，존재우석류적경피、근피화과피중。위석류감구유일개독특적9-담잡쌍배[3.3.1]임완결구，해결구여탁품동유사，시일사활성물질적주요골가。본문종술위석류감적제취、합성방법급기연생물재생물활성화합성방면적응용，지출연구위석류감적제취화생물활성、진일보합성경가신영적위석류감연생물병연구기응용시연구위석류감급기연생물하일보수요해결적문제。
Pseudopelletierine is an important alkaloid which exists in the pomegranate stem bark, root bark and pericarp. Pseud-opelletierine has a unique 9-azabicyclo [3. 3. 1] nonane structure which is the analogue of tropinone and main skeleton of some active substances. We summarized the extraction, synthesis methods of pseudopelletierine and the application of both biological activity and synthetic aspects of its derivatives. Meanwhile, the studies of pseudopelletierine extraction, biological activities, novel pseudopelletier-ine derivatives synthesis and application are the future research direction.