CAJ | 학술논문

目的：探讨影响自然周期冻融胚胎移植临床妊娠成功的因素。方法对南京市妇幼保健院生殖医学中心2011年1月至2013年12月行自然周期冻融胚胎移植治疗的282例患者的资料采用非条件Logistic回归分析法进行分析,并对回归分析的结果进行进一步的研究。结果患者年龄、卵泡排出时间(其中的hCG注射后24小时内排卵组)、移植不同发育阶段胚胎与妊娠结局相关(偏回归系数分别为：-0.052,0.446,-0.081,均P<0.05)。不孕年限、移植胚胎数目、子宫内膜厚度与妊娠结局无显著关系(均P>0.05)。肌注绒毛膜促性腺激素(hCG)后24小时内卵泡排出者临床妊娠率高于未注射hCG组及48小时内卵泡排出者(χ2值分别为3.880和4.660,均P<0.05)。移植囊胚与卵裂期胚胎相比,具有更高的临床妊娠率。结论年龄、卵泡排出时间、不同发育时期胚胎是影响自然周期冻融胚胎移植临床妊娠的重要因素。
목적：탐토영향자연주기동융배태이식림상임신성공적인소。방법대남경시부유보건원생식의학중심2011년1월지2013년12월행자연주기동융배태이식치료적282례환자적자료채용비조건Logistic회귀분석법진행분석,병대회귀분석적결과진행진일보적연구。결과환자년령、란포배출시간(기중적hCG주사후24소시내배란조)、이식불동발육계단배태여임신결국상관(편회귀계수분별위：-0.052,0.446,-0.081,균P<0.05)。불잉년한、이식배태수목、자궁내막후도여임신결국무현저관계(균P>0.05)。기주융모막촉성선격소(hCG)후24소시내란포배출자림상임신솔고우미주사hCG조급48소시내란포배출자(χ2치분별위3.880화4.660,균P<0.05)。이식낭배여란렬기배태상비,구유경고적림상임신솔。결론년령、란포배출시간、불동발육시기배태시영향자연주기동융배태이식림상임신적중요인소。
Objective To investigate the influential factors of clinical pregnancy outcomes of women receiving natural cycle frozen-thawed embryo transfer. Methods Non-conditional Logistic regression analysis was conducted on the clinical data of 282 cases receiving natural cycle frozen-thawed embryo transfer during the period of January 2011 to December 2013 in Nanjing Maternal and Child Health Hospital. Results Patient’ s age, ovulation ( happened within 24 hours after hCG intramuscular injection ) and embryo at different stage were correlated with pregnancy outcomes (partial regression coefficient was -0. 052, 0. 446 and -0. 081, respectively, all P <0. 05). Duration of infertility, endometrial thickness and the number of embryo transplantation had no relation with clinical pregnancy outcomes (all P>0. 05). Cases whose ovulation happened within 24 hours after hCG intramuscular injection got higher clinical pregnancy rate than that of the cases without hCG injection and those whose follicles discharged within 48 hours after hCG injection (χ2 value was 3. 880 and 4. 660, respectively, both P<0. 05). Besides, blastocysts were easier to grow compared with embryos at cleavage stage. Conclusion Age, the timing of ovulation and embryo at developmental stages are the key influential factors of natural cycle frozen-thawed embryo transfer.