中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
476-478,487
,共4页
支原体肺炎%心血管系统%并发症%危险因素
支原體肺炎%心血管繫統%併髮癥%危險因素
지원체폐염%심혈관계통%병발증%위험인소
mycoplasma pneumoniae ( MP)%cardiovascular system%complications%risk factors
目的：探讨支原体肺炎患儿心血管系统损害的临床特点及相关危险因素。方法回顾性分析自2013年1月至2014年6月期间宁波市鄞州区茅山社区卫生服务中心收治的189例支原体肺炎患儿的临床资料，采集患血管系统损害的临床表现，并对发生心血管系统损害的相关危险因素进行单因素以及多因素Logistic回归分析。结果在189例肺炎支原体感染患儿中，共有42例并发肺外心血管系统损害，发病率为22.2%；多因素Logistic回归分析提示：年龄(OR=2.452)、热程(OR=1.337)、C-反应蛋白(OR=1.563)、发热程度(OR=1.310)、大环内酯类抗生素应用起始时间(OR=2.452)与支原体肺炎患儿肺外心血管系统损害均呈正相关(均P<0.05)，而CD4+/CD8+比值升高(OR=0.679)则为保护性因素(P<0.05)。结论年龄、热程、高C-反应蛋白、发热程度、大环内酯类抗生素应用起始时间及低血清CD4+/CD8+比值是肺炎支原体感染患儿肺外心血管系统损害的高危因素，临床应根据这些高危因素制定防止措施以改善患儿的预后。
目的：探討支原體肺炎患兒心血管繫統損害的臨床特點及相關危險因素。方法迴顧性分析自2013年1月至2014年6月期間寧波市鄞州區茅山社區衛生服務中心收治的189例支原體肺炎患兒的臨床資料，採集患血管繫統損害的臨床錶現，併對髮生心血管繫統損害的相關危險因素進行單因素以及多因素Logistic迴歸分析。結果在189例肺炎支原體感染患兒中，共有42例併髮肺外心血管繫統損害，髮病率為22.2%；多因素Logistic迴歸分析提示：年齡(OR=2.452)、熱程(OR=1.337)、C-反應蛋白(OR=1.563)、髮熱程度(OR=1.310)、大環內酯類抗生素應用起始時間(OR=2.452)與支原體肺炎患兒肺外心血管繫統損害均呈正相關(均P<0.05)，而CD4+/CD8+比值升高(OR=0.679)則為保護性因素(P<0.05)。結論年齡、熱程、高C-反應蛋白、髮熱程度、大環內酯類抗生素應用起始時間及低血清CD4+/CD8+比值是肺炎支原體感染患兒肺外心血管繫統損害的高危因素，臨床應根據這些高危因素製定防止措施以改善患兒的預後。
목적：탐토지원체폐염환인심혈관계통손해적림상특점급상관위험인소。방법회고성분석자2013년1월지2014년6월기간저파시은주구모산사구위생복무중심수치적189례지원체폐염환인적림상자료，채집환혈관계통손해적림상표현，병대발생심혈관계통손해적상관위험인소진행단인소이급다인소Logistic회귀분석。결과재189례폐염지원체감염환인중，공유42례병발폐외심혈관계통손해，발병솔위22.2%；다인소Logistic회귀분석제시：년령(OR=2.452)、열정(OR=1.337)、C-반응단백(OR=1.563)、발열정도(OR=1.310)、대배내지류항생소응용기시시간(OR=2.452)여지원체폐염환인폐외심혈관계통손해균정정상관(균P<0.05)，이CD4+/CD8+비치승고(OR=0.679)칙위보호성인소(P<0.05)。결론년령、열정、고C-반응단백、발열정도、대배내지류항생소응용기시시간급저혈청CD4+/CD8+비치시폐염지원체감염환인폐외심혈관계통손해적고위인소，림상응근거저사고위인소제정방지조시이개선환인적예후。
Objective To investigate the clinical characteristics of cardiovascular system damage in children with mycoplasma pneumoniae ( MP) and related risk factors. Methods A retrospective analysis was conducted on the clinical data of 189 children with MP treated during the period of January 2013 to June 2014 in Ningbo Yinzhou District Maoshan Community Health Service Center, and clinical manifestations of cardiovascular system damage were collected. Related risk factors of cardiovascular system damage were analyzed by univariate and multivariate Logistic regression analysis. Results Of 189 cases with MP, 42 children were complicated with cardiovascular system damage, and the incidence was 22. 2%. Multivariate Logistic regression analysis showed that age (OR=2. 452), course of fever (OR=1. 337), CRP (OR=1. 563), degree of fever (OR=1. 310) and starting time of macrolides antibiotics application (OR=2. 452) were positively correlated with cardiovascular system damage (all P <0. 05), but CD4 + /CD8 +(OR =0. 679)inereasing was protective factors(P <0. 05). Conclusion Age, course of fever, CRP, degree of fever, starting time of macrolides antibiotics application and low CD4 + /CD8 +are high risk factors of cardiovascular system damage in children with MP. Clinical measures should be taken to improve prognosis of patient children against these risk factors.
