中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
482-484,485
,共4页
先天性梅毒%新生儿%梅毒血清学%甲苯胺红不加热血清试验%梅毒螺旋体血细胞凝试验
先天性梅毒%新生兒%梅毒血清學%甲苯胺紅不加熱血清試驗%梅毒螺鏇體血細胞凝試驗
선천성매독%신생인%매독혈청학%갑분알홍불가열혈청시험%매독라선체혈세포응시험
congenital syphilis%neonate%toluidine red unheated serum test,TRUST%syphilis serology%treponema pallidum haemagglutination,TPHA
目的：探讨妊娠梅毒孕妇甲苯胺红不加热血清试验( TRUST)滴度对其所产新生儿梅毒血清学的影响。方法对舟山市妇幼保健院2009年8月至2011年8月期间56例妊娠梅毒母亲所生56例新生儿于出生时进行梅毒螺旋体血细胞凝试验( TPHA)和TRUST检测,于生后3、6、9、12和18月龄时进行血清学检测,并对梅毒血清学指标进行随访,对治疗结果进行分析。结果56例新生儿中,3例新生儿于出生时诊断为先天梅毒儿,其中2例为早产儿于出生后死亡,1例住院予正规治疗。53例疑似先天梅毒儿,出生时TPHA均为阳性,12例(22.64%)TRUST为阳性,滴度1：1~1：4；52例(1例失访)随访对象的TPHA于18个月龄时全部转阴,12例新生儿阳性TRUST于6月龄时全部转阴,所有病例在随访期间未出现TRUST滴度上升,至随访结束,52例疑似先天梅毒儿均排除了先天梅毒感染的可能。结论对妊娠早、中期发现的梅毒患者通过正规、足量的抗梅毒治疗可以降低先天性梅毒的发生率。通过对新生儿进行长期的梅毒血清学随访,提高了对梅毒血清学的认识,可为临床诊断和治疗先天性梅毒提供帮助。
目的：探討妊娠梅毒孕婦甲苯胺紅不加熱血清試驗( TRUST)滴度對其所產新生兒梅毒血清學的影響。方法對舟山市婦幼保健院2009年8月至2011年8月期間56例妊娠梅毒母親所生56例新生兒于齣生時進行梅毒螺鏇體血細胞凝試驗( TPHA)和TRUST檢測,于生後3、6、9、12和18月齡時進行血清學檢測,併對梅毒血清學指標進行隨訪,對治療結果進行分析。結果56例新生兒中,3例新生兒于齣生時診斷為先天梅毒兒,其中2例為早產兒于齣生後死亡,1例住院予正規治療。53例疑似先天梅毒兒,齣生時TPHA均為暘性,12例(22.64%)TRUST為暘性,滴度1：1~1：4；52例(1例失訪)隨訪對象的TPHA于18箇月齡時全部轉陰,12例新生兒暘性TRUST于6月齡時全部轉陰,所有病例在隨訪期間未齣現TRUST滴度上升,至隨訪結束,52例疑似先天梅毒兒均排除瞭先天梅毒感染的可能。結論對妊娠早、中期髮現的梅毒患者通過正規、足量的抗梅毒治療可以降低先天性梅毒的髮生率。通過對新生兒進行長期的梅毒血清學隨訪,提高瞭對梅毒血清學的認識,可為臨床診斷和治療先天性梅毒提供幫助。
목적：탐토임신매독잉부갑분알홍불가열혈청시험( TRUST)적도대기소산신생인매독혈청학적영향。방법대주산시부유보건원2009년8월지2011년8월기간56례임신매독모친소생56례신생인우출생시진행매독라선체혈세포응시험( TPHA)화TRUST검측,우생후3、6、9、12화18월령시진행혈청학검측,병대매독혈청학지표진행수방,대치료결과진행분석。결과56례신생인중,3례신생인우출생시진단위선천매독인,기중2례위조산인우출생후사망,1례주원여정규치료。53례의사선천매독인,출생시TPHA균위양성,12례(22.64%)TRUST위양성,적도1：1~1：4；52례(1례실방)수방대상적TPHA우18개월령시전부전음,12례신생인양성TRUST우6월령시전부전음,소유병례재수방기간미출현TRUST적도상승,지수방결속,52례의사선천매독인균배제료선천매독감염적가능。결론대임신조、중기발현적매독환자통과정규、족량적항매독치료가이강저선천성매독적발생솔。통과대신생인진행장기적매독혈청학수방,제고료대매독혈청학적인식,가위림상진단화치료선천성매독제공방조。
Objective To explore the influence of toluidine red unheated serum test ( TRUST) titer of maternal syphilis on neonatal syphilis serology. Methods A total of 56 neonates of mothers with syphilis in Health Care for Women and Children of Zhoushan City delivered between August 2009 and August 2011 were recruited in this study, and they underwent treponema pallidum haemagglutination ( TPHA) and TRUST at birth. Serology detection was done at 3, 6, 9, 12 and 18 months old, and the serology indexes were followed up for analysis. Results There were 3 of 56 neonates diagnosed with congenital syphilis at birth, including 2 premature neonates died after birth and one case accepting standard treatments in hospital. At birth TPHA was positive in 53 suspected cases, and TRUST was positive in 12 (22. 64%) neonates with the titer ranging from1:1 to 1:4. Except for one case lost in follow-up, all of the other cases became negative for TPHA within 18 months, and 12 cases became negative in TRUST within 6 months after birth. The titer of TRUST did not increase for all neonates during follow-up. Congenital syphilis was ruled out in 52 suspected cases. Conclusion Regular and standard anti-syphilis treatment for early and metaphase maternal syphilis can reduce the incidence of congenital syphilis. Long-term follow-up of syphilis serology in neonates improves the cognition on syphilis serology, which can provide assistance for clinical diagnosis and treatment of congenital syphilis.
