中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2015年
3期
496-498
,共3页
赵秋彦%盘宗敏%梁国泉%陈笑娟
趙鞦彥%盤宗敏%樑國泉%陳笑娟
조추언%반종민%량국천%진소연
妊娠%解脲支原体%人型支原体%药敏试验
妊娠%解脲支原體%人型支原體%藥敏試驗
임신%해뇨지원체%인형지원체%약민시험
pregnancy%ureaplasma urealytium ( Uu)%mycoplasma hominis ( Mh)%drug sensitivity test
目的：分析广州市南沙区不良妊娠患者生殖道支原体感染及药敏状况,为指导临床合理用药提供参考。方法于2011年1月至2013年12月,随机选择广州市南沙区第一人民医院及南沙区妇幼保健院妇产科就诊的患者共计750例作为观察组,其中不孕245例、习惯性流产266例、早产239例；按年龄、职业、文化程度和营养状况,以1：1匹配选取同期正常孕产妇750例作为对照组,对两组526例研究对象进行支原体培养及药敏测定。结果观察组解脲支原体( Uu)、人型支原体( Mh)和Uu+Mh检出率分别为58.40%、3.07%和3.87%,均显著高于对照组(χ2值分别为358.66、7.411、7.247,均P<0.01)；观察组中各类病例组支原体检出率比较无显著性差异(均P>0.05),其中观察组中不孕、习惯性流产者、早产Uu的检出率均高于对照组(χ2值分别为231.856、224.418、227.530,均P<0.05)；观察组中不孕、习惯性流产者 Mh和 Uu+Mh检出率均高于对照组(χ2值分别为5.642、8.181；2.849、8.841；均P<0.05)。 Uu对甲砜霉素、美满霉素和交沙霉素都具有较高的敏感性(85.71%~77.71%),Mh对强力霉素、交沙霉素和美满霉素高度敏感(90.32%~100.00%)；Uu+Mh对交沙霉素、强力霉素、美满霉素均具有较高的敏感性(80.49%~87.80%)。结论生殖道支原体感染能引起不孕症、习惯性流产及早产等；监测其药敏变迁对合理用药非常重要。
目的：分析廣州市南沙區不良妊娠患者生殖道支原體感染及藥敏狀況,為指導臨床閤理用藥提供參攷。方法于2011年1月至2013年12月,隨機選擇廣州市南沙區第一人民醫院及南沙區婦幼保健院婦產科就診的患者共計750例作為觀察組,其中不孕245例、習慣性流產266例、早產239例；按年齡、職業、文化程度和營養狀況,以1：1匹配選取同期正常孕產婦750例作為對照組,對兩組526例研究對象進行支原體培養及藥敏測定。結果觀察組解脲支原體( Uu)、人型支原體( Mh)和Uu+Mh檢齣率分彆為58.40%、3.07%和3.87%,均顯著高于對照組(χ2值分彆為358.66、7.411、7.247,均P<0.01)；觀察組中各類病例組支原體檢齣率比較無顯著性差異(均P>0.05),其中觀察組中不孕、習慣性流產者、早產Uu的檢齣率均高于對照組(χ2值分彆為231.856、224.418、227.530,均P<0.05)；觀察組中不孕、習慣性流產者 Mh和 Uu+Mh檢齣率均高于對照組(χ2值分彆為5.642、8.181；2.849、8.841；均P<0.05)。 Uu對甲砜黴素、美滿黴素和交沙黴素都具有較高的敏感性(85.71%~77.71%),Mh對彊力黴素、交沙黴素和美滿黴素高度敏感(90.32%~100.00%)；Uu+Mh對交沙黴素、彊力黴素、美滿黴素均具有較高的敏感性(80.49%~87.80%)。結論生殖道支原體感染能引起不孕癥、習慣性流產及早產等；鑑測其藥敏變遷對閤理用藥非常重要。
목적：분석엄주시남사구불량임신환자생식도지원체감염급약민상황,위지도림상합리용약제공삼고。방법우2011년1월지2013년12월,수궤선택엄주시남사구제일인민의원급남사구부유보건원부산과취진적환자공계750례작위관찰조,기중불잉245례、습관성유산266례、조산239례；안년령、직업、문화정도화영양상황,이1：1필배선취동기정상잉산부750례작위대조조,대량조526례연구대상진행지원체배양급약민측정。결과관찰조해뇨지원체( Uu)、인형지원체( Mh)화Uu+Mh검출솔분별위58.40%、3.07%화3.87%,균현저고우대조조(χ2치분별위358.66、7.411、7.247,균P<0.01)；관찰조중각류병례조지원체검출솔비교무현저성차이(균P>0.05),기중관찰조중불잉、습관성유산자、조산Uu적검출솔균고우대조조(χ2치분별위231.856、224.418、227.530,균P<0.05)；관찰조중불잉、습관성유산자 Mh화 Uu+Mh검출솔균고우대조조(χ2치분별위5.642、8.181；2.849、8.841；균P<0.05)。 Uu대갑풍매소、미만매소화교사매소도구유교고적민감성(85.71%~77.71%),Mh대강력매소、교사매소화미만매소고도민감(90.32%~100.00%)；Uu+Mh대교사매소、강력매소、미만매소균구유교고적민감성(80.49%~87.80%)。결론생식도지원체감염능인기불잉증、습관성유산급조산등；감측기약민변천대합리용약비상중요。
Objective To analyze the infection of mycoplasma hominis (Mh) and ureaplasma urealytium (Uu) and drug sensitivity of abnormal pregnant patients from Nansha district in Guangzhou city, so as to offer reference for clinical rational drug use. Methods During January 2011 to December 2013, 750 cases, including 245 cases of sterility, 266 cases of habitual abortion and 239 cases of premature, were randomized sampling into case group. Another 750 normal pregnant women were pair matched into control group according to age, occupation, cultural degree and nutrition condition. Mh and Uu culture and drug sensitivity test were done among 526 samples. Results The detection rates of Uu, Mh and Uu+Mh were 58. 40%, 3. 07% and 3. 87% respectively in observation group, which were higher than those of the control group (χ2 value was 358. 66,7. 411 and 7. 247, respectively, all P<0. 01). The detection rate of all case groups didn’t show significant differences (all P>0. 05), but that of Uu was higher in cases of sterility, habitual abortion and premature than the control group (χ2 value was 231. 856, 224. 418 and 227. 530, respectively, all P<0. 05). In the observation group the detection rate of Mh and Uu+Mh was higher in cases of infertility and those of habitual abortion than in control group (χ2 value was 5. 642, 8. 181, 2. 849 and 8. 841, respectively, all P<0. 05). Uu was sensitive to thiamphenicol, minocycline and josamycin (85. 71% -77. 71%), Mh to doxycycline, josamycin and minocycline (90. 32% -100. 00%), and Uu+Mh to josamycin, doxycycline and minocycline (80. 49% -87. 80%), respectively. Conclusion Mycoplasma infection of reproductive tract can cause sterility, habitual abortion and premature. Monitoring drug resistance of mycoplasma is very important for using medicine rationally.
