临床普外科电子杂志
臨床普外科電子雜誌
림상보외과전자잡지
Journal of General Surgery for Clinicians (Electronic Version)
2014年
4期
7-9
,共3页
miR-126%VEGF%乳腺癌%RT-PCR
miR-126%VEGF%乳腺癌%RT-PCR
miR-126%VEGF%유선암%RT-PCR
MiR-126%VEGF%Breast cancer%RT-PCR
目的：研究乳腺癌组织和癌旁组织中血管内皮生长因子（vascular endothelial growth factor,VEGF）和miR-126的表达及其临床意义。方法运用实时定量的方法检测57例乳腺癌患者的癌组织及癌旁组织中VEGF和miR-126的表达情况。结果 VEGF和miR-126在乳腺癌组织中表达阳性率分别为84.2%和3.5%， VEGF和miR-126在癌旁组织中表达的阳性率分别为5.26%和85.9%,二者比较差异具有统计学意义（P<0.05）。结论 miR-126在乳腺癌组织中担任抑癌基因的角色。可能成为将来乳腺癌诊断和治疗的一个新的靶点。
目的：研究乳腺癌組織和癌徬組織中血管內皮生長因子（vascular endothelial growth factor,VEGF）和miR-126的錶達及其臨床意義。方法運用實時定量的方法檢測57例乳腺癌患者的癌組織及癌徬組織中VEGF和miR-126的錶達情況。結果 VEGF和miR-126在乳腺癌組織中錶達暘性率分彆為84.2%和3.5%， VEGF和miR-126在癌徬組織中錶達的暘性率分彆為5.26%和85.9%,二者比較差異具有統計學意義（P<0.05）。結論 miR-126在乳腺癌組織中擔任抑癌基因的角色。可能成為將來乳腺癌診斷和治療的一箇新的靶點。
목적：연구유선암조직화암방조직중혈관내피생장인자（vascular endothelial growth factor,VEGF）화miR-126적표체급기림상의의。방법운용실시정량적방법검측57례유선암환자적암조직급암방조직중VEGF화miR-126적표체정황。결과 VEGF화miR-126재유선암조직중표체양성솔분별위84.2%화3.5%， VEGF화miR-126재암방조직중표체적양성솔분별위5.26%화85.9%,이자비교차이구유통계학의의（P<0.05）。결론 miR-126재유선암조직중담임억암기인적각색。가능성위장래유선암진단화치료적일개신적파점。
Objective To study the expression of VEGF and miR-126 in breast cancer tissues.Methods The expression of VEGF and miR-126 was detected in 57 cases including malignant and benign tissues by using RT-PCR.Results the positive expression rate of VEGF and miR-126 were 84.2% and 3.5% in breast tissues, the positive expression rate of VEGF and miR-126 were 5.26% and 85.9% in para-carcinoma tissues, the differences of the two were statistically significant (P<0.05).ConclusionmiR-126 plays a role of inhibiting breast cancer in tissues of breast cancer, miR-126 could be a potential target in breast cancer treatment.
