CAJ | 학술논문

目的：探讨早、中期帕金森病（parkinson’s disease，PD）患者的视空间感知能力和视空间物体组织能力损害特点。方法选取早、中期 PD 患者19例以及人口学资料与其相匹配的18例健康对照组作为研究被试，神经心理学背景测试采用简易精神状态评价量表（MMSE）、汉密顿抑郁量表（HAMD）、数字广度、词汇流畅性，Stroop 字色干扰实验以及听觉词汇学习等测试被试的总体认知、情绪、记忆以及执行功能。采用视觉线段方向判断测试被试视空间的感知能力，采用 Hooper 视觉组织任务测试被试的视空间物体的组织能力。结果相对于正常对照组，早、中期 PD 患者在词汇流畅性，Stroop 字色干扰实验，听觉词汇的延迟再认差异均有统计学意义（P ＜0．05）。在视空间能力方面，PD 组在视觉线段方向能力与对照组差异无统计学意义（P ＞0．05）；而在 Hooper 视觉组织任务中，PD 组的视空间物体的组织能力较对照组明显下降，差异有统计学意义（P ＜0．05）；经 Pearson 相关分析，我们发现 PD 患者的视空间物体的组织能力与其疾病的严重程度并没有明显相关性（P ＞0．05）。结论早、中期 PD 患者不仅存在记忆及执行功能损害，同时视空间能力损害，而这种视空间能力损害可能主要表现为视空间物体的组织和重建能力。
목적：탐토조、중기파금삼병（parkinson’s disease，PD）환자적시공간감지능력화시공간물체조직능력손해특점。방법선취조、중기 PD 환자19례이급인구학자료여기상필배적18례건강대조조작위연구피시，신경심이학배경측시채용간역정신상태평개량표（MMSE）、한밀돈억욱량표（HAMD）、수자엄도、사회류창성，Stroop 자색간우실험이급은각사회학습등측시피시적총체인지、정서、기억이급집행공능。채용시각선단방향판단측시피시시공간적감지능력，채용 Hooper 시각조직임무측시피시적시공간물체적조직능력。결과상대우정상대조조，조、중기 PD 환자재사회류창성，Stroop 자색간우실험，은각사회적연지재인차이균유통계학의의（P ＜0．05）。재시공간능력방면，PD 조재시각선단방향능력여대조조차이무통계학의의（P ＞0．05）；이재 Hooper 시각조직임무중，PD 조적시공간물체적조직능력교대조조명현하강，차이유통계학의의（P ＜0．05）；경 Pearson 상관분석，아문발현 PD 환자적시공간물체적조직능력여기질병적엄중정도병몰유명현상관성（P ＞0．05）。결론조、중기 PD 환자불부존재기억급집행공능손해，동시시공간능력손해，이저충시공간능력손해가능주요표현위시공간물체적조직화중건능력。
Objective To investigate the characteristics of visuospatial information processing impairment in early/moderate stages Pa-kinsion’s disease (PD)patients.Methods A total of 19 individuals with idiopathic PD were compared with matched healthy controls (HC)on the judgment of line orientation test (JLOT)and the hooper visual organization task (HVOT).A series of battery including the assessment of global cognition,emotion,memory and executive function was also administered.The severity of disease was assessed based on the Hohen and Yahr scale and motor section of the Unified parkinson's Disease Rating Scale (UPDRS -section Ⅲ).Results The results showed that the PD group impaired on verbal fluency,memory and executive function (all P <0.05).In visuospatial in-formation processing tasks,there were no significant differences between the PD and HC groups in the JLOT test (P >0.05);Howev-er,the results showed that the score of the HOVT task with PD patients was significantly lower than that of HC group (P <0.05).The study indicated the score of the HOVT task for PD was not correlated with the degrees of severity to clinical symptom.Conclusions The results indicated that the PD patients in the early/moderate stages not only impaired on memory and executive function,but also im-paired on visuospatial information organization and construction.