CAJ | 학술논문

目的：考察生脉注射液用5％葡萄糖注射液（5％GS）、10％葡萄糖注射液（10％GS）、0．9％氯化钠注射液（0．9％NS）、葡萄糖氯化钠注射液（GNS）和乳酸钠林格注射液（SLR）调配后成品输液的稳定性。方法洁净条件下，生脉注射液用上述5种输液调配为成品输液，室温（25℃）8 h 内观察成品输液的性状、pH、不溶性微粒数及 HPLC 法检测五味子醇甲的含量变化。结果5种成品输液的外观、pH 及五味子醇甲含量均无明显变化；用5％GS、10％GS、0．9％NS 和 GNS 调配的成品输液，4 h 内不溶性微粒符合2010年版《中国药典》一部规定，但用 SLR 调配的成品输液不溶性微粒不符合其规定。结论生脉注射液可以用5％GS、10％GS、0．9％NS 或 GNS 调配为成品输液，并在4 h 内使用。
목적：고찰생맥주사액용5％포도당주사액（5％GS）、10％포도당주사액（10％GS）、0．9％록화납주사액（0．9％NS）、포도당록화납주사액（GNS）화유산납림격주사액（SLR）조배후성품수액적은정성。방법길정조건하，생맥주사액용상술5충수액조배위성품수액，실온（25℃）8 h 내관찰성품수액적성상、pH、불용성미립수급 HPLC 법검측오미자순갑적함량변화。결과5충성품수액적외관、pH 급오미자순갑함량균무명현변화；용5％GS、10％GS、0．9％NS 화 GNS 조배적성품수액，4 h 내불용성미립부합2010년판《중국약전》일부규정，단용 SLR 조배적성품수액불용성미립불부합기규정。결론생맥주사액가이용5％GS、10％GS、0．9％NS 혹 GNS 조배위성품수액，병재4 h 내사용。
Objective To explore the compatible stability of Shengmai injection with 5% glucose injection (5%GS),10% glucose in-jection (10%GS),0.9% sodium chloride injection (0.9%NS),glucose and sodium chloride injection (GNS)and sodium lactate Ringer's injection (SLR).Methods At room temperature,Shengmai injection was mixed with the above 5 infusion solutions,and then the appearance,pH value,insoluble particle and the content of Schisandrin were observed within 8 h under clean conditions.Results No significant changes were found in the appearance,pH value and the content of Schisandrin of all mixed solutions within 8 h;the number of insoluble particles in the mixture of 5% GS,0.9% NS,10% GS and GNS conformed to the standard of Chinese Pharmaco-peias within 4h.Conclusion Shengmai injection should be mixed with 5% GS ,0.9% NS,10% GS or GNS and be used within 4 h.