中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
12期
1188-1190
,共3页
超声诊断%颈动脉内-中膜增厚%幽门杆菌感染%血清巨噬细胞移动抑制因子
超聲診斷%頸動脈內-中膜增厚%幽門桿菌感染%血清巨噬細胞移動抑製因子
초성진단%경동맥내-중막증후%유문간균감염%혈청거서세포이동억제인자
ultrasound diagnosis%internal carotid artery-media thickness%helicobacter pylori infection%serum migra-tion inhibitory factor
目的：探讨超声诊断颈动脉内－中膜增厚者幽门杆菌感染对血清巨噬细胞移动抑制因子（MIF）的影响。方法将进行颈动脉内－中膜厚度（IMT）彩超的258例患者根据IMT彩超结果分为2组，对照组145例为IMT没有增厚者，试验组113例为IMT增厚者。检测2组患者血清MIF和血清幽门螺旋杆菌抗体（ Hp－IgG），同时用单因素分析IMT增厚的危险因素，用多因素Logistic分析血清MIF和血清Hp－IgG的关系。结果2组患者IMT、血清Hp－IgG、血清MIF之间比较差异有统计学意义（ P＜0．05）。与对照组比较，试验组血清MIF和血清Hp－IgG水平明显升高（ P＜0．05）。用多因素Logistic回归分析得出血清MIF和血清Hp－IgG是IMT增厚的独立危险因素。在IMT增厚者中进一步分析显示，血清MIF 和血清Hp －IgG水平呈正相关。结论血清 MIF 和血清Hp－IgG为IMT增厚者的独立危险因素，同时IMT增厚者中幽门杆菌感染与血清MIF水平间呈正相关。
目的：探討超聲診斷頸動脈內－中膜增厚者幽門桿菌感染對血清巨噬細胞移動抑製因子（MIF）的影響。方法將進行頸動脈內－中膜厚度（IMT）綵超的258例患者根據IMT綵超結果分為2組，對照組145例為IMT沒有增厚者，試驗組113例為IMT增厚者。檢測2組患者血清MIF和血清幽門螺鏇桿菌抗體（ Hp－IgG），同時用單因素分析IMT增厚的危險因素，用多因素Logistic分析血清MIF和血清Hp－IgG的關繫。結果2組患者IMT、血清Hp－IgG、血清MIF之間比較差異有統計學意義（ P＜0．05）。與對照組比較，試驗組血清MIF和血清Hp－IgG水平明顯升高（ P＜0．05）。用多因素Logistic迴歸分析得齣血清MIF和血清Hp－IgG是IMT增厚的獨立危險因素。在IMT增厚者中進一步分析顯示，血清MIF 和血清Hp －IgG水平呈正相關。結論血清 MIF 和血清Hp－IgG為IMT增厚者的獨立危險因素，同時IMT增厚者中幽門桿菌感染與血清MIF水平間呈正相關。
목적：탐토초성진단경동맥내－중막증후자유문간균감염대혈청거서세포이동억제인자（MIF）적영향。방법장진행경동맥내－중막후도（IMT）채초적258례환자근거IMT채초결과분위2조，대조조145례위IMT몰유증후자，시험조113례위IMT증후자。검측2조환자혈청MIF화혈청유문라선간균항체（ Hp－IgG），동시용단인소분석IMT증후적위험인소，용다인소Logistic분석혈청MIF화혈청Hp－IgG적관계。결과2조환자IMT、혈청Hp－IgG、혈청MIF지간비교차이유통계학의의（ P＜0．05）。여대조조비교，시험조혈청MIF화혈청Hp－IgG수평명현승고（ P＜0．05）。용다인소Logistic회귀분석득출혈청MIF화혈청Hp－IgG시IMT증후적독립위험인소。재IMT증후자중진일보분석현시，혈청MIF 화혈청Hp －IgG수평정정상관。결론혈청 MIF 화혈청Hp－IgG위IMT증후자적독립위험인소，동시IMT증후자중유문간균감염여혈청MIF수평간정정상관。
Objective To evaluate the effect of helicobacter pylori ca-rotid intima-media thickening through ultrasound diagnosis on on serum levels of macrophage migration inhibitory factor( MIF).Methods A to-tal of 258 cases underwent carotid artery intima-media thickness(IMT) were selected from 2010 January to 2014 January in our hospital according to the IMT color doppler results and were divided into 2 groups.A total of 145 cases in the control group were diagnosed without thickening , and 113 cases with thickening were divided into the treatment group.The data of serum MIF and serum Helicobacter pylori antibody ( Hp-IgG) were detected and the single factor analysis on risk of IMT thickening was done.while the multi-factor Logistic analysis on rela-tionship between serum MIF and Hp -IgG was done.Results There were statistical difference on IMT, serum Hp -IgG and MIF in two groups( P<0.05).Compared with control group, the data of serum MIF and serum Hp -IgG level increased significantly in treatment group (P<0.05).Multivariate Logistic regression analysis showed that serum MIF and Hp -IgG were independent risk factors of IMT thickening. Further analysis showed that in the thicker IMT, serum MIF and serum Hp-IgG levels were positively correlated.Conclusion Serum MIF and Hp-IgG are independent risk factors of IMT thickening, helicobacter pylori infection and the serum level of MIF is positively correlated.
