实用医院临床杂志
實用醫院臨床雜誌
실용의원림상잡지
PRACTICAL JOURNAL OF CLINICAL MEDICINE
2015年
4期
15-17
,共3页
脑出血%基质金属蛋白酶-9%细胞纤维连接蛋白%脑水肿
腦齣血%基質金屬蛋白酶-9%細胞纖維連接蛋白%腦水腫
뇌출혈%기질금속단백매-9%세포섬유련접단백%뇌수종
Intracerebral hemorrhage%Matrix metalloproteinase-9%Cellular fibronectin%Perihematomal edema
目的：探讨脑出血患者血清基质金属蛋白酶－9（ matrix metalloproteinase－9，MMP－9）、细胞纤维连接蛋白（cellular fibronectin，cFN）水平及其与脑血肿和周围水肿体积的关系。方法收集24例符合入选标准的脑出血患者（脑出血组），同期健康体检者15例为对照组。测定脑出血组患者发病后1d、3d、7d 血清 MMP－9、cFN 水平；发病当日及5～7d 时行头颅 CT测定血肿及周围水肿体积，分析 MMP－9、cFN 水平与脑血肿及周围水肿体积的关系。结果脑出血组各时间点血清 MMP－9、cFN水平明显高于正常对照组（均 P ＜0．05），其中发病3d 时血清 MMP－9、cFN 水平升高最明显；MMP－9与出血灶周围水肿体积的绝对值呈正相关，cFN 与血肿体积呈正相关（均 P ＜0．05）；未发现血清 MMP －9与 cFN 两者间有相关性。结论脑出血患者血清 MMP－9及 cFN 代谢异常，血清 MMP－9及 cFN 水平可间接反映脑出血患者脑组织损伤的严重程度，对其含量测定有助于判断病情。
目的：探討腦齣血患者血清基質金屬蛋白酶－9（ matrix metalloproteinase－9，MMP－9）、細胞纖維連接蛋白（cellular fibronectin，cFN）水平及其與腦血腫和週圍水腫體積的關繫。方法收集24例符閤入選標準的腦齣血患者（腦齣血組），同期健康體檢者15例為對照組。測定腦齣血組患者髮病後1d、3d、7d 血清 MMP－9、cFN 水平；髮病噹日及5～7d 時行頭顱 CT測定血腫及週圍水腫體積，分析 MMP－9、cFN 水平與腦血腫及週圍水腫體積的關繫。結果腦齣血組各時間點血清 MMP－9、cFN水平明顯高于正常對照組（均 P ＜0．05），其中髮病3d 時血清 MMP－9、cFN 水平升高最明顯；MMP－9與齣血竈週圍水腫體積的絕對值呈正相關，cFN 與血腫體積呈正相關（均 P ＜0．05）；未髮現血清 MMP －9與 cFN 兩者間有相關性。結論腦齣血患者血清 MMP－9及 cFN 代謝異常，血清 MMP－9及 cFN 水平可間接反映腦齣血患者腦組織損傷的嚴重程度，對其含量測定有助于判斷病情。
목적：탐토뇌출혈환자혈청기질금속단백매－9（ matrix metalloproteinase－9，MMP－9）、세포섬유련접단백（cellular fibronectin，cFN）수평급기여뇌혈종화주위수종체적적관계。방법수집24례부합입선표준적뇌출혈환자（뇌출혈조），동기건강체검자15례위대조조。측정뇌출혈조환자발병후1d、3d、7d 혈청 MMP－9、cFN 수평；발병당일급5～7d 시행두로 CT측정혈종급주위수종체적，분석 MMP－9、cFN 수평여뇌혈종급주위수종체적적관계。결과뇌출혈조각시간점혈청 MMP－9、cFN수평명현고우정상대조조（균 P ＜0．05），기중발병3d 시혈청 MMP－9、cFN 수평승고최명현；MMP－9여출혈조주위수종체적적절대치정정상관，cFN 여혈종체적정정상관（균 P ＜0．05）；미발현혈청 MMP －9여 cFN 량자간유상관성。결론뇌출혈환자혈청 MMP－9급 cFN 대사이상，혈청 MMP－9급 cFN 수평가간접반영뇌출혈환자뇌조직손상적엄중정도，대기함량측정유조우판단병정。
Objective To investigate the dynamic changes of serum levels of matrix metalloproteinase -9(MMP-9)and cellular fibronectin(cFN)in patients with intracerebral hemorrhage (ICH)and the relationship between the two markers and the volumes of he -matoma and perihematomal edema (PHE).Methods Twenty-four ICH patients were confirmed by CT to meet the entry criteria and 15 healthy people were served as controls .Levels of serum MMP-9 and cFN were measured on the day 1,3 and 7 after onset.The volumes of hematoma and its peripheral edema were evaluated by CT on day of onset and 5 to 7 days after onset.The relationship between the two serum markers and the pathological changes were analyzed .Results Levels of serum MMP-9 and cFN were significant higher in ICH patients at each time point after onset than those in normal controls (all P <0.05).The highest levels of serum MMP-9 and cFN were found on day 3 after onset.The MMP-9 level was positively correlated with PHE while cFN level was positively correlated with he -matoma volume.However,no obvious relationship was observed between MMP -9 and cFN levels.Conclusion There is an abnormal metabolism of MMP-9 and cFN in ICH patients.Serum levels of MMP-9 and cFN may reflect the damage severity of brain tissue .It is of helpful to diagnose patients'conditions.
