CAJ | 학술논문

目的：评价二氧化碳结合间苯三酚在结肠镜检查中对患者的阵痛疗效及安全性。方法入选进行结肠镜检查的患者164例，分为试验组88例和对照组76例。2组患者检查前3 d进食易消化食物，12 h和6 h前分次口服聚乙二醇电解质散清洁肠道，用二氧化碳作为肠镜检查的膨胀气体。试验组检查前10 min肌内注射间苯三酚40 mg，对照组肌内注射0．9％氯化钠2 mL。2组患者用视觉模拟评分（ VAS）记录结肠镜检查过程中的疼痛评分，并观察2组患者结肠镜达到盲肠的例数及检查前、检查中和检查后血压及心率变化。结果试验组和对照组检查过程中VAS疼痛评分分别为（4．1±1．4）和（6．3±1．5），试验组显著低于对照组（ P＜0．05）。试验组结肠镜达到盲肠者80例，达盲率为90．9％，对照组结肠镜达到盲肠者68例，达盲率为89．5％，差异无统计学意义（ P＞0．05）。试验组与对照组结肠镜检查前、检查中及检查后收缩压、舒张压及心率差异均无统计学意义（ P＞0．05）。结论用二氧化碳作为肠镜检查的膨胀气体，同时术前肌内注射间苯三酚可显著减轻患者结肠镜检查过中的疼痛，且无明显不良反应发生。
목적：평개이양화탄결합간분삼분재결장경검사중대환자적진통료효급안전성。방법입선진행결장경검사적환자164례，분위시험조88례화대조조76례。2조환자검사전3 d진식역소화식물，12 h화6 h전분차구복취을이순전해질산청길장도，용이양화탄작위장경검사적팽창기체。시험조검사전10 min기내주사간분삼분40 mg，대조조기내주사0．9％록화납2 mL。2조환자용시각모의평분（ VAS）기록결장경검사과정중적동통평분，병관찰2조환자결장경체도맹장적례수급검사전、검사중화검사후혈압급심솔변화。결과시험조화대조조검사과정중VAS동통평분분별위（4．1±1．4）화（6．3±1．5），시험조현저저우대조조（ P＜0．05）。시험조결장경체도맹장자80례，체맹솔위90．9％，대조조결장경체도맹장자68례，체맹솔위89．5％，차이무통계학의의（ P＞0．05）。시험조여대조조결장경검사전、검사중급검사후수축압、서장압급심솔차이균무통계학의의（ P＞0．05）。결론용이양화탄작위장경검사적팽창기체，동시술전기내주사간분삼분가현저감경환자결장경검사과중적동통，차무명현불량반응발생。
Objective To evaluate the clinical efficacy and safety of phloroglucinol in patients during coloscopy.Methods A total of 164 patients who were prepared for coloscopy were randomized divided into experiment group ( n =88 ) and control group ( n =76 ) . All of the patients in the two groups were given food easy to digest 3 days before coloscopy and given polyethylene glycol electrolyte powder orally 12 and 6 hours before coloscopy.The carbom dioxide was used as the expansion of the gas, and patients in the experiment group were given phloro-glucinol 40 mg by intramuscular injection 10 minutes before the colosco-py, and those in the control group were given 0.9%NaCl 2 mL by intra-muscular injection.The data of visual analogue score( VAS) , rate of co-loscopy examination reached to the cecum, blood pressure and heart rate before and after the examination between the two groups were recorded. Results The VAS score were ( 4.1 ±1.4 ) and ( 6.3 ±1.5 ) points in the experiment and control group respectively, with experiment group significantly lower than the control group ( P<0.05 ) .The reach cecum rate was 90.9%in experiment group and 89.5%in control group, which indicated no statistical difference between the two groups ( P>0.05 ) .The blood pressure and heart rate of the two groups were not statistically different in the procedure of coloscopy (P>0.05).Conclusion Phloroglucinol can significantly decrease the VAS in the procedure of coloscopy, without increasing the incidence of adverse drug reactions.