中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
17期
29-30
,共2页
不同剂量%尿激酶%复杂性肺炎旁胸腔积液
不同劑量%尿激酶%複雜性肺炎徬胸腔積液
불동제량%뇨격매%복잡성폐염방흉강적액
Different doses%Urokinase%Complicated parapneumonic effusions
目的：探讨不同剂量的尿激酶在治疗复杂性肺炎旁胸腔积液中的疗效。方法将48复杂性例肺炎旁胸腔积液患者随机分为大剂量尿激酶治疗组和小剂量尿激酶对照组，大剂量治疗组26例，小剂量对照组22例。大剂量治疗组首次胸腔抽液后注入含25万u尿激酶的生理盐水20 mL，小剂量对照组给予含尿激酶10万u的生理盐水20 mL。比较两组胸腔积液引流量、住院时间及治疗效果。结果在规则抗感染的治疗下，大剂量治疗组平均胸液引流量(1840±100)mL、平均住院时间为(20.4±2)d，大剂量治疗组总有效率92.3%；小剂量对照组平均胸液引流量(1420±90) mL，平均住院时间为(27.2±2)d，总有效率63.6%，比较两组平均胸液引流量、平均住院时间及总有效率差异有统计学意义(P<0.05)。不良反应两组无差异。结论胸腔引流后腔内应用大剂量尿激酶25万u，能显著增加胸水引流量，减少住院时间，疗效满意，且未出现明显的毒副作用。
目的：探討不同劑量的尿激酶在治療複雜性肺炎徬胸腔積液中的療效。方法將48複雜性例肺炎徬胸腔積液患者隨機分為大劑量尿激酶治療組和小劑量尿激酶對照組，大劑量治療組26例，小劑量對照組22例。大劑量治療組首次胸腔抽液後註入含25萬u尿激酶的生理鹽水20 mL，小劑量對照組給予含尿激酶10萬u的生理鹽水20 mL。比較兩組胸腔積液引流量、住院時間及治療效果。結果在規則抗感染的治療下，大劑量治療組平均胸液引流量(1840±100)mL、平均住院時間為(20.4±2)d，大劑量治療組總有效率92.3%；小劑量對照組平均胸液引流量(1420±90) mL，平均住院時間為(27.2±2)d，總有效率63.6%，比較兩組平均胸液引流量、平均住院時間及總有效率差異有統計學意義(P<0.05)。不良反應兩組無差異。結論胸腔引流後腔內應用大劑量尿激酶25萬u，能顯著增加胸水引流量，減少住院時間，療效滿意，且未齣現明顯的毒副作用。
목적：탐토불동제량적뇨격매재치료복잡성폐염방흉강적액중적료효。방법장48복잡성례폐염방흉강적액환자수궤분위대제량뇨격매치료조화소제량뇨격매대조조，대제량치료조26례，소제량대조조22례。대제량치료조수차흉강추액후주입함25만u뇨격매적생리염수20 mL，소제량대조조급여함뇨격매10만u적생리염수20 mL。비교량조흉강적액인류량、주원시간급치료효과。결과재규칙항감염적치료하，대제량치료조평균흉액인류량(1840±100)mL、평균주원시간위(20.4±2)d，대제량치료조총유효솔92.3%；소제량대조조평균흉액인류량(1420±90) mL，평균주원시간위(27.2±2)d，총유효솔63.6%，비교량조평균흉액인류량、평균주원시간급총유효솔차이유통계학의의(P<0.05)。불량반응량조무차이。결론흉강인류후강내응용대제량뇨격매25만u，능현저증가흉수인류량，감소주원시간，료효만의，차미출현명현적독부작용。
Objective To investigate the efficacy of different doses of urokinase in the treatment of complicated parapneumonic effusion. Methods 48 patients with complicated parapneumonic effusion were randomly divided into large dose injection group (the treatment group, n=26) and small dose injection group (the control group,n=22). After first pumping pleural effusion, patients in the treatment and those in the control group received injection of 20 mL saline containing urokinase 250000 U and 20 mL saline con-taining urokinase 100000 U, respectively. We compared the pleural effusion drainage, duration of hospitalization and outcomes in both groups. Results Under the rules of anti-infective treatment, the treatment group could be significantly increased pleural fluid drainage, shorter hospital stays , the difference was significant (P<0.05). the total efficient was 92.3%in the treatment group,and in the control group the total efficient was 63.6%. The difference was significant (P<0.05 ). Conclusion Injection of Urokinase 250000 U after retaining tube in thorax for drainage can significantly increase in pleural fluid drainage and shorten hospitalization time. The curative effect is satisfied and without obvious adverse reactions.
