中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
19期
101-102
,共2页
IL-17%自身免疫性肝炎%肝纤维化
IL-17%自身免疫性肝炎%肝纖維化
IL-17%자신면역성간염%간섬유화
IL-17%Autoimmune hepatitis%Hepatic fibrosis
目的:研究IL-17在自身免疫性肝炎肝组织中的表达及意义。方法:选取自身免疫性肝炎患者45例,经肝穿收集其肝组织,对照组选取正常肝组织10例,采用免疫组化的方法检测肝组织中的IL-17的表达情况,并探讨IL-17与自身免疫性肝炎纤维化分期相关性。结果:自身免疫性肝炎患者肝组织IL-17阳性的表达量高于对照组(P<0.01), IL-17和自身免疫性肝炎肝纤维化程度相关。结论:IL-17可能参与了自身免疫性肝病的发病过程,降低IL-17活性程度,可能会减轻自身免疫性肝炎发病和纤维化程度。
目的:研究IL-17在自身免疫性肝炎肝組織中的錶達及意義。方法:選取自身免疫性肝炎患者45例,經肝穿收集其肝組織,對照組選取正常肝組織10例,採用免疫組化的方法檢測肝組織中的IL-17的錶達情況,併探討IL-17與自身免疫性肝炎纖維化分期相關性。結果:自身免疫性肝炎患者肝組織IL-17暘性的錶達量高于對照組(P<0.01), IL-17和自身免疫性肝炎肝纖維化程度相關。結論:IL-17可能參與瞭自身免疫性肝病的髮病過程,降低IL-17活性程度,可能會減輕自身免疫性肝炎髮病和纖維化程度。
목적:연구IL-17재자신면역성간염간조직중적표체급의의。방법:선취자신면역성간염환자45례,경간천수집기간조직,대조조선취정상간조직10례,채용면역조화적방법검측간조직중적IL-17적표체정황,병탐토IL-17여자신면역성간염섬유화분기상관성。결과:자신면역성간염환자간조직IL-17양성적표체량고우대조조(P<0.01), IL-17화자신면역성간염간섬유화정도상관。결론:IL-17가능삼여료자신면역성간병적발병과정,강저IL-17활성정도,가능회감경자신면역성간염발병화섬유화정도。
Objective:To study the expression and significance of IL-17 in autoimmune hepatitis liver tissue.Methods:45 patients with autoimmune hepatitis were selected.The liver tissue was selected through liver biopsy.The control group selected 10 cases of normal liver tissues.The IL-17 expression in the liver tissue was detected by immunohistochemical method,and the relevance between IL-17 and autoimmune hepatitis fibrosis staging was explored.Results:The IL-17 positive expression in the liver tissue of patients with autoimmune hepatitis was higher than that of the control group(P<0.01).IL-17 had relevance with autoimmune hepatitis fibrosis degree.Conclusion:IL-17 may be involved in the pathogenesis process of autoimmune liver disease.Reducing the activity degree of IL-17 may reduce the incidence of autoimmune hepatitis and fibrosis degree.