中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
12期
1103-1105
,共3页
王国华%唐黎明%马玉亮%孙一峰%黄洪亮%徐妙军%费晓舟
王國華%唐黎明%馬玉亮%孫一峰%黃洪亮%徐妙軍%費曉舟
왕국화%당려명%마옥량%손일봉%황홍량%서묘군%비효주
下肢深静脉血栓%巴曲酶%低分子肝素%临床疗效%安全性
下肢深靜脈血栓%巴麯酶%低分子肝素%臨床療效%安全性
하지심정맥혈전%파곡매%저분자간소%림상료효%안전성
deep venous thrombosis%batroxobin%low molecular heparin%clinical efficacy%safety
目的：评价巴曲酶联合低分子肝素治疗老年患者下肢深静脉血栓的临床疗效和安全性。方法将65例老年下肢深静脉血栓患者随机分为试验组32例和对照组33例。对照组予以低分子肝素5000 U皮下注射，bid；试验组在对照组基础上，加用巴曲酶5 BU静脉滴注，隔日1次（首剂10 BU），总量25 BU，2组疗程均为7d。治疗后，比较2组患者的临床疗效、血液学指标及不良反应发生率有无差别。结果试验组与对照组总有效率分别为90．63％和84．85％，差异无统计学意义（P＞0．05），但试验组显效率68．75％显著高于对照组33．33％（ P＜0．05）。试验组与对照组治疗后D－二聚体、纤维蛋白原较治疗前显著降低（P＜0．05），凝血酶原时间显著延长（P＜0．05），但治疗后组间上述指标差异无统计学意义（ P＞0．05）。2组患者轻微出血发生率分别为9．38％和6．06％（ P＞0．05）。结论巴曲酶联合低分子肝素治疗老年患者下肢深静脉血栓是安全、有效的。
目的：評價巴麯酶聯閤低分子肝素治療老年患者下肢深靜脈血栓的臨床療效和安全性。方法將65例老年下肢深靜脈血栓患者隨機分為試驗組32例和對照組33例。對照組予以低分子肝素5000 U皮下註射，bid；試驗組在對照組基礎上，加用巴麯酶5 BU靜脈滴註，隔日1次（首劑10 BU），總量25 BU，2組療程均為7d。治療後，比較2組患者的臨床療效、血液學指標及不良反應髮生率有無差彆。結果試驗組與對照組總有效率分彆為90．63％和84．85％，差異無統計學意義（P＞0．05），但試驗組顯效率68．75％顯著高于對照組33．33％（ P＜0．05）。試驗組與對照組治療後D－二聚體、纖維蛋白原較治療前顯著降低（P＜0．05），凝血酶原時間顯著延長（P＜0．05），但治療後組間上述指標差異無統計學意義（ P＞0．05）。2組患者輕微齣血髮生率分彆為9．38％和6．06％（ P＞0．05）。結論巴麯酶聯閤低分子肝素治療老年患者下肢深靜脈血栓是安全、有效的。
목적：평개파곡매연합저분자간소치료노년환자하지심정맥혈전적림상료효화안전성。방법장65례노년하지심정맥혈전환자수궤분위시험조32례화대조조33례。대조조여이저분자간소5000 U피하주사，bid；시험조재대조조기출상，가용파곡매5 BU정맥적주，격일1차（수제10 BU），총량25 BU，2조료정균위7d。치료후，비교2조환자적림상료효、혈액학지표급불량반응발생솔유무차별。결과시험조여대조조총유효솔분별위90．63％화84．85％，차이무통계학의의（P＞0．05），단시험조현효솔68．75％현저고우대조조33．33％（ P＜0．05）。시험조여대조조치료후D－이취체、섬유단백원교치료전현저강저（P＜0．05），응혈매원시간현저연장（P＜0．05），단치료후조간상술지표차이무통계학의의（ P＞0．05）。2조환자경미출혈발생솔분별위9．38％화6．06％（ P＞0．05）。결론파곡매연합저분자간소치료노년환자하지심정맥혈전시안전、유효적。
Objective To evaluate the clinical activity and safety of ba-troxobin combined with low molecular heparin in the treatment of deep venous thrombosis in elderly patients.Methods A total of 65 patients diagnosed with deep venous thrombosis were recruited in our hospital and randomly divided into control group ( n =33 ) and experiment group ( n=32 ) .Patients in the control group were given low molecular heparin 5000 U through hypodermical injection twice a day for 7 days.Patients in the experiment group were given batroxobin 5 BU qod( first dosage of 10 BU, totaling 25 BU) plus low molecular heparin 5000 U hypodermical injection twice a day for 7 days.After treatment, the clinical efficacy, serum index and safety were compared between the two groups. Results The clinical efficacy were 90.63%and 84.85%in the experi-ment and control group respectively without statistical difference (P>0.05).But the excellence rate in experiment group was significant-ly higher than that in the control group ( P <0.05 ) .The D -dimer, fibrinogen were significantly decreased and prothrombin time was signifi-cantly prolonged in the both groups after treatment ( P <0.05 ) .The slight bleeding rate were 9.38% and 6.06% in the experiment and control group respectively without statistical difference ( P >0.05 ) .Conclusion Batroxobin combined with low molecular heparin in the treatment of deep venous thrombosis in elderly patients is effective and safe.
