CAJ | 학술논문

目的：评价糖脉康颗粒对2型糖尿病患者胰岛素敏感性的影响。方法将120例2型糖尿病患者随机分为对照组60例和试验组60例。对照组予以常规的降糖、降压、调脂等治疗；试验组在常规治疗基础上，加用糖脉康颗粒15 g? d－1口服，每天3次，2组疗程均为3个月。观察2组治疗前后餐后血糖、糖化血红蛋白、空腹胰岛素水平、胰岛素敏感性、低密度脂蛋白、三酰甘油、内皮素－1及临床症状的变化，以及不良反应发生率。结果试验组总有效率88．33％明显优于对照组75．00％（ P＜0．05）。治疗后，2组患者的空腹胰岛素水平、胰岛素敏感性、餐后血糖及糖化血红蛋白较治疗前均明显改善（ P＜0．05），且试验组治疗后的改善幅度明显优于对照组（ P＜0．05）。2组患者的临床症状均较治疗前明显改善（ P＜0．05），且试验组优于对照组（ P＜0．05）。治疗后，2组三酰甘油水平均无明显改善（ P＞0．05）。治疗后，试验组低密度脂蛋白以及内皮素－1水平较治疗前明显降低（ P ＜0．05），对照组则不明显（ P＞0．05）。合并早期糖尿病肾病的治疗后，试验组内皮素－1较治疗前显著降低（P＜0．05），对照组则不明显（P ＞0．05），组间比较差异有统计学意义（ P＜0．05）。2组在治疗期间均未发生不良反应。结论糖脉康在安全有效治疗2型糖尿病的同时能改善胰岛素敏感性，减轻胰岛素抵抗，降低内皮素－1水平，尤其是降低糖尿病肾病患者的内皮素－1水平。
목적：평개당맥강과립대2형당뇨병환자이도소민감성적영향。방법장120례2형당뇨병환자수궤분위대조조60례화시험조60례。대조조여이상규적강당、강압、조지등치료；시험조재상규치료기출상，가용당맥강과립15 g? d－1구복，매천3차，2조료정균위3개월。관찰2조치료전후찬후혈당、당화혈홍단백、공복이도소수평、이도소민감성、저밀도지단백、삼선감유、내피소－1급림상증상적변화，이급불량반응발생솔。결과시험조총유효솔88．33％명현우우대조조75．00％（ P＜0．05）。치료후，2조환자적공복이도소수평、이도소민감성、찬후혈당급당화혈홍단백교치료전균명현개선（ P＜0．05），차시험조치료후적개선폭도명현우우대조조（ P＜0．05）。2조환자적림상증상균교치료전명현개선（ P＜0．05），차시험조우우대조조（ P＜0．05）。치료후，2조삼선감유수평균무명현개선（ P＞0．05）。치료후，시험조저밀도지단백이급내피소－1수평교치료전명현강저（ P ＜0．05），대조조칙불명현（ P＞0．05）。합병조기당뇨병신병적치료후，시험조내피소－1교치료전현저강저（P＜0．05），대조조칙불명현（P ＞0．05），조간비교차이유통계학의의（ P＜0．05）。2조재치료기간균미발생불량반응。결론당맥강재안전유효치료2형당뇨병적동시능개선이도소민감성，감경이도소저항，강저내피소－1수평，우기시강저당뇨병신병환자적내피소－1수평。
Objective To observe the effect of Tangmaikang particles on insulin sensitivity in the treatment of type 2 diabetes.Methods A total of 120 patients with type 2 diabetes were selected, randomly divided into control group ( n=60) and treatment group ( n=60).Patients in control group received routine hypoglycemic, hypotensive and lipid adjusting treatment, while patients in treatment group were given Tangmaikang par-ticles 15 g? d-1 on the basis of conventional treatment.The treatment lasted for 3 months.The data of postprandial plasma sugar ( PPG) , gly-cosylated hemoglobin ( HbA1 c ) , fasting insulin ( FINS ) , insulin sensi-tivity ( HOMA-IS ) , low density lipoprotein ( LDL -C ) , triglyceride (TG), endothelin -1( ET-1) and the change of clinical symptoms in two groups before and after treatment were observed as well as the inci-dence of adverse reactions in 2 groups.Results The total effective rate was 88.33% in treatment group, better than control group (75.00%) .After treatment, the data of FINS, HOMA -IS, PPG, HbA1c were all significantly improved in two groups( P<0.05 ) , and treatment group improved more obviously than control group ( P<0.05 ) .Symptoms in two groups were both improved compared with before treatment( P<0.05) , and the treatment group was better than control group( P<0.05).But the TG level wasn′t significantly decreased in two groups( P>0.05).After treatment, LDL-C and ET-1 level in treatment group were significantly decreased ( P<0.05 ) , and the control group was not obvious (P>0.05).After the treatment for early diabetic nephropathy, ET -1 in treatment group was significantly lower (P<0.05), and the control group was not obvious (P>0.05).There was no adverse reactions found during treat-ment.Conclusion Tangmaikang particles are safe and effective for type 2 diabetes, which also can improve insulin sensibility, reduce insulin resistance and ET-1 level, especially can reduce the ET-1 level of patients with diabetic nephropathy.