CAJ | 학술논문

目的：研究阿托伐他汀联合普罗布考对颈动脉粥样硬化斑块及血浆ox-LDL的影响。方法将128例有颈动脉粥样硬化斑块的患者随机分为两组，每组64例；治疗组给予阿托伐他汀和普罗布考治疗，对照组只给予阿托伐他汀治疗。共观察52周，比较两组治疗前后颈动脉内膜斑块面积、血脂以及氧化型LDL(ox-LDL)水平的变化。结果最终纳入统计者122例，与对照组相比，治疗前两组患者颈动脉粥样硬化斑块面积、血脂水平、ox-LDL水平比较，差异均无统计学意义(P>0.05)；而治疗52周后两组之间上述各项指标的比较差异均有统计学意义(P<0.01)。结论普罗布考联合阿托伐他汀治疗颈动脉粥样硬化斑块的疗效优于单纯阿托伐他汀治疗，可达到抗动脉粥样硬化、稳定斑块、抗氧化应激进而降低缺血性心脑血管病事件的目的。
목적：연구아탁벌타정연합보라포고대경동맥죽양경화반괴급혈장ox-LDL적영향。방법장128례유경동맥죽양경화반괴적환자수궤분위량조，매조64례；치료조급여아탁벌타정화보라포고치료，대조조지급여아탁벌타정치료。공관찰52주，비교량조치료전후경동맥내막반괴면적、혈지이급양화형LDL(ox-LDL)수평적변화。결과최종납입통계자122례，여대조조상비，치료전량조환자경동맥죽양경화반괴면적、혈지수평、ox-LDL수평비교，차이균무통계학의의(P>0.05)；이치료52주후량조지간상술각항지표적비교차이균유통계학의의(P<0.01)。결론보라포고연합아탁벌타정치료경동맥죽양경화반괴적료효우우단순아탁벌타정치료，가체도항동맥죽양경화、은정반괴、항양화응격진이강저결혈성심뇌혈관병사건적목적。
Objective To study the influence of Atorvastatin plus Probucol on carotid atherosclerotic plaque and plasma ox-LDL. Methods One hundred and twenty eight patients with carotid atherosclerotic plaque formation were randomly divided into two groups,64 cases in each group. Patients in the treatment group were treated with Atorvastatin plus Probucol, patients in the control group were treated with Atorvastatin alone. The plaque area,lipid and ox-LDL were measured before and 52 weeks after treatment. Results Finally 122 cases were included in the statistics.Before treat-ment there was no significant difference between two groups on carotid plaque area,lipid levels and ox-LDL level(P>0.05). But after 52 weeks treatment, the difference were remarkable(P<0.01). Conclusion Probucol combined with ator-vastatin in the treatment of carotid atherosclerotic plaque is better than pure atorvastatin treatment.Combination therapy can achieve the anti atherosclerosis plaque stability, anti oxidative stress, radical and lower ischemic cardio cerebral vascular disease objective.