CAJ | 학술논문

目的：探讨糠酸莫米松对小儿常年变应性鼻炎的临床疗效及作用机制。方法将我院就诊的178例常年变应性鼻炎患儿随机分为试验组和对照组各89例，试验组鼻内吸入糠酸莫米松，对照组口服氯雷他定，两组均治疗4周。比较两组患儿治疗前后鼻炎症状积分和儿童鼻结膜炎相关生活质量问卷(RQLQ)评分，并检测两组患儿血清白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)水平。结果治疗4周后，试验组鼻塞、鼻痒、咽痒以及总症状积分明显低于对照组(P<0.05)，鼻部症状、实际问题、其他症状以及总积分等RQLQ评分也明显低于对照组(P<0.05)。试验组IL-2水平显著高于对照组，IL-4、IL-5水平显著低于对照组，两组间相比差异具有统计学意义(P<0.05)。结论糠酸莫米松能够有效控制小儿常年变应性鼻炎的临床症状，总体疗效优于口服氯雷他定；其作用机制可能与调节Th1和Th2细胞失衡有关。
목적：탐토강산막미송대소인상년변응성비염적림상료효급작용궤제。방법장아원취진적178례상년변응성비염환인수궤분위시험조화대조조각89례，시험조비내흡입강산막미송，대조조구복록뢰타정，량조균치료4주。비교량조환인치료전후비염증상적분화인동비결막염상관생활질량문권(RQLQ)평분，병검측량조환인혈청백세포개소-2(IL-2)、백세포개소-4(IL-4)、백세포개소-5(IL-5)수평。결과치료4주후，시험조비새、비양、인양이급총증상적분명현저우대조조(P<0.05)，비부증상、실제문제、기타증상이급총적분등RQLQ평분야명현저우대조조(P<0.05)。시험조IL-2수평현저고우대조조，IL-4、IL-5수평현저저우대조조，량조간상비차이구유통계학의의(P<0.05)。결론강산막미송능구유효공제소인상년변응성비염적림상증상，총체료효우우구복록뢰타정；기작용궤제가능여조절Th1화Th2세포실형유관。
Objective To investigate the clinical efficacy and acting mechanism of mometasone furoate on the children with perennial allergic rhinitis. Methods A total of 178 children with perennial allergic rhinitis treated in our hospital were randomly divided into the experimental group and the control group, with 89 patients in each group. The experi-mental group received intranasal inhalation of mometasone furoate and the control group received oral administration of loratadine. Both groups were treated for 4 weeks. The rhinitis symptom scores and children's rhinoconjunctivitis related quality of life questionnaire (RQLQ) scores of the two groups before and after treatment were compared, and the serum interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-5 (IL-5) levels of both groups were detected. Results After 4 weeks of treatment, the experimental group was significantly lower than the control group in the nasal congestion, nasal itching, throat itching and total symptom scores (P<0.05), and was also lower than the control group in the RQLQ scores such as nasal symptom, practical problem, other symptom and total scores (P<0.05). The experimental group had significantly higher IL-2 level and significantly lower IL-4 and IL-5 levels than the control group, with statistically significant differences (P<0.05). Conclusion Mometasone furoate can effectively control the clinical symptoms of children with perennial allergic rhinitis and has better overall efficacy than oral loratadine; its acting mechanism may be related to the regulation of Th1 and Th2 cell imbalance.