CAJ | 학술논문

结直肠癌是全世界癌症死亡的主要原因之一，迫切需要寻找一种高特异性和灵敏性的肿瘤标记物，实现结直肠癌的早期诊断和预后评估。近年来研究发现，多种 microRNA 与结直肠癌密切相关。其中以microRNA-106b-25簇为典型代表，microRNA-106b-25簇包括microRNA-106b、microRNA-93和microRNA-25，这些microRNA不但能通过p21、p57及Bim来促进结直肠癌细胞增殖，抑制细胞凋亡，还能通过与抑癌基因RB和PTEN相互作用参与结肠癌的起源和发展。此外在转化生长因子β（TGF-β）信号通路中，microRNA-106b-25簇的高表达能使肿瘤细胞逃避 TGF-β诱导的生长抑制作用。因而深入研究microRNA-106b-25簇在结直肠癌发生发展中的作用，有望在其诊断、治疗以及预后评估方面提供新的思路。
결직장암시전세계암증사망적주요원인지일，박절수요심조일충고특이성화령민성적종류표기물，실현결직장암적조기진단화예후평고。근년래연구발현，다충 microRNA 여결직장암밀절상관。기중이microRNA-106b-25족위전형대표，microRNA-106b-25족포괄microRNA-106b、microRNA-93화microRNA-25，저사microRNA불단능통과p21、p57급Bim래촉진결직장암세포증식，억제세포조망，환능통과여억암기인RB화PTEN상호작용삼여결장암적기원화발전。차외재전화생장인자β（TGF-β）신호통로중，microRNA-106b-25족적고표체능사종류세포도피 TGF-β유도적생장억제작용。인이심입연구microRNA-106b-25족재결직장암발생발전중적작용，유망재기진단、치료이급예후평고방면제공신적사로。
Colorectal cancer (CRC) is a major cause of cancer mortality worldwide. In order to achieve early diagnosis and prognosis evaluation of colorectal cancer, there is an urgent need to find tumor markers with high specificity and sensitivity. In recent years, some studies have found that a variety of microRNAs are closely related with colorectal cancer. Among microRNA-106b-25 cluster which include the microRNA-106b, microRNA-93 and microRNA-25 is a typical representative. Over-expressions of these microRNAs not only promote the growth of tumor cells by negatively regulating p21 and p57, and suppress the apoptosis of tumor cells through inhibition of Bim, but also involve in the origin and development of colorectal cancer by inhibiting tumor suppressor gene of RB and PTEN. Furthermore, high expression of microRNA-106b-25 cluster might endue tumor cells with resistance to inhibitory effect of cell growth induced by TGF-β signaling path. Further research on the molecular mechanism of microRNA-106b-25 cluster in colorectal genesis and progression will provide new clue in cancer diagnosis, anticancer therapy and prognosis.