CAJ | 학술논문

目的：探讨隐匿性和症状性糖尿病下肢血管病变(PAD)患者血清血管内皮生长因子的变化，为糖尿病PAD早期筛查提供依据。方法选取我院2型糖尿病患者分为单纯糖尿病组(DM组，90例)、隐匿性PAD组(A-PAD组，93例)和症状性PAD组(S-PAD组，92例)，应用ELISA法测定三组患者血清VEGF水平，分析VEGF在三组患者中有无差别，分层后排除糖尿病视网膜病变患者后进一步分析VEGF在三组患者中的变化。结果隐匿性和症状性PAD组血清VEGF水平均高于单纯糖尿病组(P<0.05)。在排除糖尿病视网膜病变患者后，隐匿性和症状性PAD组血清VEGF仍均高于单纯糖尿病组(P<0.05)。在隐匿性和症状性PAD患者中VEGF与HbA1c正相关(r分别为0.267、0.352，P均<0.05)。结论 VEGF是糖尿病下肢血管病变的危险因素。
목적：탐토은닉성화증상성당뇨병하지혈관병변(PAD)환자혈청혈관내피생장인자적변화，위당뇨병PAD조기사사제공의거。방법선취아원2형당뇨병환자분위단순당뇨병조(DM조，90례)、은닉성PAD조(A-PAD조，93례)화증상성PAD조(S-PAD조，92례)，응용ELISA법측정삼조환자혈청VEGF수평，분석VEGF재삼조환자중유무차별，분층후배제당뇨병시망막병변환자후진일보분석VEGF재삼조환자중적변화。결과은닉성화증상성PAD조혈청VEGF수평균고우단순당뇨병조(P<0.05)。재배제당뇨병시망막병변환자후，은닉성화증상성PAD조혈청VEGF잉균고우단순당뇨병조(P<0.05)。재은닉성화증상성PAD환자중VEGF여HbA1c정상관(r분별위0.267、0.352，P균<0.05)。결론 VEGF시당뇨병하지혈관병변적위험인소。
Objective To explore the serum level of vascular endothelial growth factor (VEGF) of the patients with asymptomatic and symptomatic peripheral artery disease (PAD) in diabetics for providing evidence for screening the patients with PAD early. Methods Selected the study population including diabetics without PAD(90 cases),diabetics with asymptomatic PAD patients(93 cases)and diabetics with symptomatic PAD patients(92 cases). The level of serum VEGF was measured using enzyme linked immunosorbent assay(ELISA) and analyzed in the three groups. The varia-tion of serum VEGF was further analyzed in the three groups excluding the diabetic retinopathy in the stratified analysis. Results The serum level of VEGF with asymptomatic and symptomatic PAD in diabetics were increased,compared with the diabetics without PAD (P<0.05). Excluding the patients with diabetic retinopathy, the serum level of VEGF of the patients with asymptomatic and symptomatic PAD in diabet ics was still increased, compared with the dia betics without PAD (P<0.05). The serum level of VEGF level was significantly positively associated with HbA1c in the pa-tients with asymptomatic and symptomatic PAD in diabetics (r=0.267, 0.352, P all<0.05). Conclusion The level of serum VEGF in the patients with asymptomatic and symptomatic PAD in diabetics had been significantly increased.