中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
19期
80-82
,共3页
骨质疏松%骨密度%血清骨钙素%甲状旁腺激素%总Ⅰ型胶原氨基端前肽%25羟基维生素D
骨質疏鬆%骨密度%血清骨鈣素%甲狀徬腺激素%總Ⅰ型膠原氨基耑前肽%25羥基維生素D
골질소송%골밀도%혈청골개소%갑상방선격소%총Ⅰ형효원안기단전태%25간기유생소D
Osteoporosis%Bone mineral density%Bone glaprotein%Parathormone%P1NP%25-hydroxyvitamin D
目的：探讨骨质疏松患者骨密度与骨代谢指标之间的关系及临床意义。方法选择我院内分泌科门诊2014年6~12月间骨质疏松症患者64例、骨量低下患者113例以及健康对照组75例，男女不限。在所有研究对象中选取女性237例，其中已绝经女性138例，未绝经女性99例，检测各组骨密度、骨代谢指标等相关因素进行比较。结果骨质疏松组与骨量低下组P1NP、OC、腰椎BMD与正常对照组差异均有统计学意义(P<0.05)，骨质疏松组与骨量低下组比较，OC、腰椎BMD差异有统计学意义(P<0.05)；绝经与未绝经女性比较，P1NP、OC、腰椎BMD差异有统计学意义(P<0.05)。结论某些骨代谢标志物与骨密度之间具有一定的相关性，可在一定程度上反映骨代谢变化，各项指标可综合评价骨质疏松症各阶段，在诊断以及评价骨质疏松治疗效果方面具有一定的临床意义。
目的：探討骨質疏鬆患者骨密度與骨代謝指標之間的關繫及臨床意義。方法選擇我院內分泌科門診2014年6~12月間骨質疏鬆癥患者64例、骨量低下患者113例以及健康對照組75例，男女不限。在所有研究對象中選取女性237例，其中已絕經女性138例，未絕經女性99例，檢測各組骨密度、骨代謝指標等相關因素進行比較。結果骨質疏鬆組與骨量低下組P1NP、OC、腰椎BMD與正常對照組差異均有統計學意義(P<0.05)，骨質疏鬆組與骨量低下組比較，OC、腰椎BMD差異有統計學意義(P<0.05)；絕經與未絕經女性比較，P1NP、OC、腰椎BMD差異有統計學意義(P<0.05)。結論某些骨代謝標誌物與骨密度之間具有一定的相關性，可在一定程度上反映骨代謝變化，各項指標可綜閤評價骨質疏鬆癥各階段，在診斷以及評價骨質疏鬆治療效果方麵具有一定的臨床意義。
목적：탐토골질소송환자골밀도여골대사지표지간적관계급림상의의。방법선택아원내분비과문진2014년6~12월간골질소송증환자64례、골량저하환자113례이급건강대조조75례，남녀불한。재소유연구대상중선취녀성237례，기중이절경녀성138례，미절경녀성99례，검측각조골밀도、골대사지표등상관인소진행비교。결과골질소송조여골량저하조P1NP、OC、요추BMD여정상대조조차이균유통계학의의(P<0.05)，골질소송조여골량저하조비교，OC、요추BMD차이유통계학의의(P<0.05)；절경여미절경녀성비교，P1NP、OC、요추BMD차이유통계학의의(P<0.05)。결론모사골대사표지물여골밀도지간구유일정적상관성，가재일정정도상반영골대사변화，각항지표가종합평개골질소송증각계단，재진단이급평개골질소송치료효과방면구유일정적림상의의。
Objective To explore the correlation and clinical significance of bone mineral density and bone metabolism markers in patients with osteoporosis. Methods All 64 patients with osteoporosis and 113 patients with low bone mass in the outpatient department of endocrinology in our hospital from June 2014 to December 2014, plus 75 healthy con-trols were selected, male or female not limited. In all research subjects, 237 females were selected, among whom 138 were in postmenopausal females and 99 were premenopausal females. Relevant factors of bone mineral density and bone metabolism markers in each group were tested. All collected data were managed and analyzed by the statistical analysis software SPSS22.0. Results The differences of P1NP, OC and lumbar BMD in the osteoporosis group and low bone mass group were statistically significant compared with those in the normal control group(P<0.05). The differences of OC and lumbar BMD compared between the osteoporosis group and low bone mass group were statistically significant(P<0.05); in the comparison between postmenopausal females and premenopausal females, the differences of P1NP, OC,and lumbar BMD were statistically significant(P<0.05). Conclusion Some bone metabolism markers and bone mineral density have a certain correlation,which is able to reflect the changes of bone metabolism to some extent. Each marker is able to comprehensively assess each phase of osteoporosis,and shows certain clinical significance in the diagnosis of osteoporosis and in the assessment of its curative efficacy.
