CAJ | 학술논문

目的：观察不同剂量异甘草酸镁治疗抗结核药物致药物性肝炎的临床疗效。方法：收治抗结核药物致药物性肝炎患者150例，随机分3组，分别采用100 mg、150 mg、200 mg异甘草酸镁治疗，监测患者血清ALT、AST，观察临床症状缓解情况及不良反应。结果：3组患者治疗2周、4周后血清ALT、AST均有显著改善，但200 mg剂量组患者血清ALT、AST改善及症状缓解情况明显优于150 mg和100 mg剂量组，150 mg剂量组明显优于100 mg剂量组，随剂量增加疗效提高；治疗4周较2周后血清ALT、AST有明显改善。结论：异甘草酸镁治疗抗结核药物致药物性肝炎疗效显著，疗效与剂量成正相关，要有足够的疗程，且无严重不良反应。
목적：관찰불동제량이감초산미치료항결핵약물치약물성간염적림상료효。방법：수치항결핵약물치약물성간염환자150례，수궤분3조，분별채용100 mg、150 mg、200 mg이감초산미치료，감측환자혈청ALT、AST，관찰림상증상완해정황급불량반응。결과：3조환자치료2주、4주후혈청ALT、AST균유현저개선，단200 mg제량조환자혈청ALT、AST개선급증상완해정황명현우우150 mg화100 mg제량조，150 mg제량조명현우우100 mg제량조，수제량증가료효제고；치료4주교2주후혈청ALT、AST유명현개선。결론：이감초산미치료항결핵약물치약물성간염료효현저，료효여제량성정상관，요유족구적료정，차무엄중불량반응。
Objective:To observe the clinical curative effect of different doses of magnesium isoglycyrrhizinate in the treatment of drug hepatitis caused by antituberculosis drugs.Methods:150 patients with drug hepatitis caused by antituberculosis drugs were selected.They were randomly divided into 3 groups,and respectively given 100 mg,150 mg,200 mg of magnesium isoglycyrrhizinate treatment.The serum ALT,AST of patients were monitored.The clinical symptoms remission condition and adverse reaction were observed.Results:The serum ALT,AST of patients in 3 groups were significantly improved after treatment for 2 weeks,4 weeks.But the serum ALT,AST improvement and symptoms remission condition of patients in the 200 mg dose group were significantly better than those of the 150 mg and the 100 mg dose group.The 150 mg dose group was significantly better than that of the 100 mg dose group.The curative effect was improved with the increase of the dose.The serum ALT,AST after treatment for 4 weeks were significantly improved than those after 2 weeks.Conclusion:Magnesium isoglycyrrhizinate in the treatment of drug hepatitis caused by antituberculosis drugs has the significant curative effect.The curative effect is positively correlated with the dose.There must be enough course of treatment,and there has no serious adverse reaction.