CAJ | 학술논문

目的：分析吲哚美辛诱导的急性小肠损伤及奥美拉唑的预防和治疗作用。方法：选择健康SD雄性大鼠20只，分为四组，正常对照组、模型组、预防组、治疗组各5只，对照组采用羟甲基纤维素溶液灌胃，其余三组采用吲哚美辛溶液灌胃，并对预防组、治疗组注射奥美拉唑。比较四组大鼠的小肠情况。结果：对照组大鼠一切正常，模型组小肠损伤指数明显（P＜0.05）。预防组、治疗组小肠损伤指数低于模型组，且治疗组实验室指标优于模型组（P＜0.05）。结论：吲哚美辛具有诱导急性小肠损伤的作用，奥美拉唑用于吲哚美辛诱导的急性小肠损伤，可以起到较好的预防及治疗作用。
목적：분석신타미신유도적급성소장손상급오미랍서적예방화치료작용。방법：선택건강SD웅성대서20지，분위사조，정상대조조、모형조、예방조、치료조각5지，대조조채용간갑기섬유소용액관위，기여삼조채용신타미신용액관위，병대예방조、치료조주사오미랍서。비교사조대서적소장정황。결과：대조조대서일절정상，모형조소장손상지수명현（P＜0.05）。예방조、치료조소장손상지수저우모형조，차치료조실험실지표우우모형조（P＜0.05）。결론：신타미신구유유도급성소장손상적작용，오미랍서용우신타미신유도적급성소장손상，가이기도교호적예방급치료작용。
Objective The effect of prevention and treatment of acute intestinal injury induced by indomethacin and omeprazole. Methods Healthy male SD 20 rats, were divided into four groups, normal control group, model group, prevention group, treatment group with 5 rats in each group, the control group using carboxymethyl cellulose solution by gavage, the other three groups were intragastric administration of indomethacin solution, and the prevention group, treatment group with omeprazole. Comparison of four groups of rat small intestine. Results The rats in control group were all normal, model group of small intestine injury index was significantly (P<0.05). The prevention group, the treatment group of small intestine injury index was lower than that of model group and treatment group, laboratory indicators better than the model group (P<0.05). Conclusion The indomethacin induced acute intestinal injury, omeprazole for acute intestinal injury induced by indomethacin, can play a better role of prevention and treatment.