CAJ | 학술논문

目的分析图片动词联想、单纯图片命名、词语语义判断3种视觉呈现语言任务在汉语母语者中的血氧水平依赖功能磁共振成像(BOLD-fMRI)语言区定位特点,并探讨其在神经外科临床中的应用. 方法 12名健康志愿者分别执行图片动词联想、单纯图片命名、词语语义判断任务,所得图像数据应用SPM8软件进行分析,生成不同语言任务的脑激活图后进行研究,并计算不同语言任务的偏侧化指数. 结果 3种语言任务在额叶及颞叶均出现了明显的左侧偏侧化,图片动词联想任务激活了包括左额下回(BA44、BA45)、左岛叶(BA13)、左颞中回(BA39)、左颞横回(BA41)、左颞上回(BA41)、左顶下小叶(BA40)、左缘上回(BA40)、左角回(BA39)等传统语言区在内的广泛皮层及皮层下网络;而单纯图片命名激活了部分传统皮层语言区,如左额下回(BA44、BA45)、左颞中回(BA39)、左顶下小叶(BA40)、左颞上回(BA22);词语语义判断任务也激活了部分传统皮层语言区,如左额下回(BA44、BA45). 结论图片动词联想、单纯图片命名、词语语义判断任务均可激活语言网络中的多个皮层脑区,不同语言任务的激活区体现不同的认知过程及加工特点,图片动词联想更适合汉语母语者神经外科术前BOLD-fMRI语言区定位.
목적 분석도편동사련상、단순도편명명、사어어의판단3충시각정현어언임무재한어모어자중적혈양수평의뢰공능자공진성상(BOLD-fMRI)어언구정위특점,병탐토기재신경외과림상중적응용. 방법 12명건강지원자분별집행도편동사련상、단순도편명명、사어어의판단임무,소득도상수거응용SPM8연건진행분석,생성불동어언임무적뇌격활도후진행연구,병계산불동어언임무적편측화지수. 결과 3충어언임무재액협급섭협균출현료명현적좌측편측화,도편동사련상임무격활료포괄좌액하회(BA44、BA45)、좌도협(BA13)、좌섭중회(BA39)、좌섭횡회(BA41)、좌섭상회(BA41)、좌정하소협(BA40)、좌연상회(BA40)、좌각회(BA39)등전통어언구재내적엄범피층급피층하망락;이단순도편명명격활료부분전통피층어언구,여좌액하회(BA44、BA45)、좌섭중회(BA39)、좌정하소협(BA40)、좌섭상회(BA22);사어어의판단임무야격활료부분전통피층어언구,여좌액하회(BA44、BA45). 결론 도편동사련상、단순도편명명、사어어의판단임무균가격활어언망락중적다개피층뇌구,불동어언임무적격활구체현불동적인지과정급가공특점,도편동사련상경괄합한어모어자신경외과술전BOLD-fMRI어언구정위.
Objective To investigate the activated brain regions of functional MRI with 3 language tasks in normal adult subjects whose native language is Chinese and provide reference to the selection of proper language task to mapping language areas.Methods Twelve right-handed normal volunteers whose native language was Mandarin participated in this study.They underwent functional MRI with a 1.5 T MR scanner when performing picture verb generation (VG),pure picture naming (PN) and abstract/concrete semantic judgment (A/C) tasks,respectively.The SPM8 software was used to analyze the data to obtain functional activated regions and calculate the lateralization indexes.Results The lateralization indexes indicated a significant lateralized activation of left hemisphere by all 3 language tasks.As to the activation of traditional language areas,the VG task activated left inferior frontal gyrus (BA44 and BA45),left insula (BA13),left middle temporal gyrus (BA39),left transverse temporal gyrus (BA41),left superior temporal gyrus (BA41),left inferior parietal lobule (BA40),left supramarginal gyrus (BA40),left angular gyrus (BA39).The PN task activated left inferior frontal gyrus (BA44 and BA45),left middle temporal gyrus (BA39),left inferior parietal lobule (BA40),left superior temporal gyrus (BA22).The A/C task only activated left inferior frontal gyrus (BA44 and BA45).Conclusions Each of the 3 language tasks can activate some parts of the cerebral network which dedicates to language processing and has its own characteristic according to the different processing pattern.VG task is more appropriate for preoperative language mapping for Chinese subjects.