中国美容医学
中國美容醫學
중국미용의학
CHINESE JOURNAL OF AESTHETIC MEDICINE
2015年
12期
40-44
,共5页
李春%周为军%宋朝辉%李朝阳%余萍%曾学文%郭智龙
李春%週為軍%宋朝輝%李朝暘%餘萍%曾學文%郭智龍
리춘%주위군%송조휘%리조양%여평%증학문%곽지룡
皮肤鳞癌%基底细胞癌%免疫组化%活化转录因子3%4%ki-67
皮膚鱗癌%基底細胞癌%免疫組化%活化轉錄因子3%4%ki-67
피부린암%기저세포암%면역조화%활화전록인자3%4%ki-67
squamous cell carcinoma%basal cell carcinoma%immunohistochemical method%activating transcription factor 3,4%ki-67
目的:探讨活化转录因子3、4和ki-67在皮肤鳞癌和基底细胞癌中的表达及其临床意义。方法:从笔者所在医院病理科储存的蜡块中随机选择96例皮肤鳞癌和118例基底细胞癌标本,采用免疫组织化学方法检测组织中活化转录因子3、4和ki-67的表达,分析其表达意义。结果:活化转录因子3、4在皮肤鳞癌中的表达较基底细胞癌高,差异有统计学意义(P值分别为0.003和0.001)。Ki-67在两种皮肤癌中的表达无显著差异(P值为0.718)。ATF3、4的表达强度和皮肤鳞癌分化程度成正相关,即分化程度低越低,表达强度越高(r=0.395 P=0.000和r=0.303 P=0.001)。结论:活化转录因子3、4可以作为鉴别皮肤鳞癌和基底细胞癌可靠的蛋白标记物和皮肤鳞癌恶性程度及预后的判断指标。
目的:探討活化轉錄因子3、4和ki-67在皮膚鱗癌和基底細胞癌中的錶達及其臨床意義。方法:從筆者所在醫院病理科儲存的蠟塊中隨機選擇96例皮膚鱗癌和118例基底細胞癌標本,採用免疫組織化學方法檢測組織中活化轉錄因子3、4和ki-67的錶達,分析其錶達意義。結果:活化轉錄因子3、4在皮膚鱗癌中的錶達較基底細胞癌高,差異有統計學意義(P值分彆為0.003和0.001)。Ki-67在兩種皮膚癌中的錶達無顯著差異(P值為0.718)。ATF3、4的錶達彊度和皮膚鱗癌分化程度成正相關,即分化程度低越低,錶達彊度越高(r=0.395 P=0.000和r=0.303 P=0.001)。結論:活化轉錄因子3、4可以作為鑒彆皮膚鱗癌和基底細胞癌可靠的蛋白標記物和皮膚鱗癌噁性程度及預後的判斷指標。
목적:탐토활화전록인자3、4화ki-67재피부린암화기저세포암중적표체급기림상의의。방법:종필자소재의원병이과저존적사괴중수궤선택96례피부린암화118례기저세포암표본,채용면역조직화학방법검측조직중활화전록인자3、4화ki-67적표체,분석기표체의의。결과:활화전록인자3、4재피부린암중적표체교기저세포암고,차이유통계학의의(P치분별위0.003화0.001)。Ki-67재량충피부암중적표체무현저차이(P치위0.718)。ATF3、4적표체강도화피부린암분화정도성정상관,즉분화정도저월저,표체강도월고(r=0.395 P=0.000화r=0.303 P=0.001)。결론:활화전록인자3、4가이작위감별피부린암화기저세포암가고적단백표기물화피부린암악성정도급예후적판단지표。
Objective To discuss the expression of activating transcription factor 3,activating transcription factor 4(ATF3,4)and ki-67 in skin squamous carcinomas and basal cell carcinomas and their clinical significances. Methods Using immunohistochemical method to detect ATF3,4 and ki-67 expression in 96 cases of skin squamous carcinoma and 118 cases of basal cell carcinoma tissues,which were randomly selected from the hospital preserved in pathology department,then analysis the meaning of expression. Results ATF3,4 in skin squamous carcinomas is higher than that in basal cell carcinomas,the differences were statistically significant(P=0.003 and 0.001, respectively), but there was no difference for ki-67(P=0.718).Positive correlation could be found between ATF3,4 expression strength and skin squamous cell carcinoma differentiation(r=0.395,P=0.000;r=0.303,P=0.001,respectively). Conclusion ATF3,4 may be used as the reliable differential protein markers between skin squamous cell carcinoma and basal cell carcinoma,and they be seen as malignant degree and prognosis indexes of cutaneous squamous cell.