CAJ | 학술논문

目的了解环境低硒地区和适宜硒地区农村老年人指甲硒水平,分析指甲硒水平的影响因素.方法从山东和四川两省分别选择环境适宜硒地区和环境低硒地区的2 000名农村老年人作为研究对象,于2003-2005年开展基线人群调查,2010-2012年开展随访调查,采集手指指甲样品,分别采用2,3-二氨基萘荧光法和原子荧光法检测硒含量.结果基线调查总人群(n=2 000)指甲硒含量均值为(0.414±0.183)mg/kg,随访人群(n=1 209)的基线调查时指甲硒含量均值为(0.413±0.181)mg/kg,随访调查时指甲硒含量均值为(0.463±0.183)mg/kg,随访人群指甲硒水平分别高于基线调查总人群和基线调查时的自身水平(P均＜0.05).基线调查显示,女性指甲硒含量[(0.432±0.186)mg/kg]高于男性指甲硒含量[(0.392±0.176)mg/kg,P＜0.05];非吸烟者指甲硒含量[(0.423±0.187)mg/kg]高于吸烟者指甲硒含量[(0.403±0.177) mg/kg,P＜0.05];非饮酒者指甲硒含量[(0.442±0.176)mg/kg]高于饮酒者指甲硒含量[(0.376±0.185) mg/kg,P＜0.05];指甲硒含量与体质指数呈正相关(r=0.230,P＜ 0.05),年龄与指甲硒含量的相关性无统计学意义(r=-0.037,P＞0.05).结论 2010-2012年随访的老人指甲硒水平较2003-2005年略有升高,指甲硒水平可受到性别、吸烟、饮酒、体质指数等多种因素的影响.
목적 료해배경저서지구화괄의서지구농촌노년인지갑서수평,분석지갑서수평적영향인소.방법 종산동화사천량성분별선택배경괄의서지구화배경저서지구적2 000명농촌노년인작위연구대상,우2003-2005년개전기선인군조사,2010-2012년개전수방조사,채집수지지갑양품,분별채용2,3-이안기내형광법화원자형광법검측서함량.결과 기선조사총인군(n=2 000)지갑서함량균치위(0.414±0.183)mg/kg,수방인군(n=1 209)적기선조사시지갑서함량균치위(0.413±0.181)mg/kg,수방조사시지갑서함량균치위(0.463±0.183)mg/kg,수방인군지갑서수평분별고우기선조사총인군화기선조사시적자신수평(P균＜0.05).기선조사현시,녀성지갑서함량[(0.432±0.186)mg/kg]고우남성지갑서함량[(0.392±0.176)mg/kg,P＜0.05];비흡연자지갑서함량[(0.423±0.187)mg/kg]고우흡연자지갑서함량[(0.403±0.177) mg/kg,P＜0.05];비음주자지갑서함량[(0.442±0.176)mg/kg]고우음주자지갑서함량[(0.376±0.185) mg/kg,P＜0.05];지갑서함량여체질지수정정상관(r=0.230,P＜ 0.05),년령여지갑서함량적상관성무통계학의의(r=-0.037,P＞0.05).결론 2010-2012년수방적노인지갑서수평교2003-2005년략유승고,지갑서수평가수도성별、흡연、음주、체질지수등다충인소적영향.
Objective To observe the nail selenium level of rural elderly population in environmental low selenium and optimal selenium areas,and explore main factors associated with nail selenium level.Methods Two thousand subjects aged 65 or older were recruited from environmental low and optimal selenium rural areas in Sichuan and Shandong provinces.Two surveys were carried out respectively from 2003 to 2005 and from 2010 to 2012.Finger nail samples were collected and the trace amount of selenium was detected with 2,3-diaminonaphthalene fluorometric determination method and atomic fluorescence spectrophotometric method,respectively.Results The average nail selenium level was (0.414 ± 0.183)μg/g for the total population (n =2 000) at baseline,(0.413 ± 0.181)mg/kg for the follow-up population (n =1 209) at baseline and (0.463 ± 0.183)mg/kg at the follow-up.The selenium level of the follow-up population was slightly higher than that of the total population and that of itself at baseline (all P ＜ 0.05).For the total population at baseline,the average nail selenium level was (0.392 ± 0.176)mg/kg for the male and (0.432 ± 0.186)mg/kg for the female,(0.403 ± 0.177)mg/kg for the smoker and (0.423 ± 0.187)mg/kg for the non-smoker,0.376 ± 0.185)mg/kg for alcohol consumer and (0.442 ± 0.176)mg/kg for the non-alcohol consumer,a positive correlation between body mass index and nail selenium level was observed (r =0.230,P ＜ 0.05),while no significant correlation between age and nail selenium level was observed (r =-0.037,P ＞ 0.05).Conclusion The nail selenium levels of the follow-up population has grown slightly higher in 7 years,nail selenium level could be affected by several factom including gender,smoking,drinking and body mass index.