CAJ | 학술논문

目的：探讨美沙拉嗪联合金双歧治疗溃疡性结肠炎的疗效及其对患者细胞因子的影响。方法选择2010年1月至2014年1月在彭山县人民医院接受治疗的溃疡性结肠炎患者126例为研究对象，按照随机数字表法分成用对照组和观察组，各63例。对照组单纯服用美沙拉嗪，每次1 g，每日3次。观察组服用美沙拉嗪，每次1 g，每日3次；同时口服金双歧治疗，每次4粒，每日3次。两组疗程均为2个月。结果治疗后，观察组患者疾病活动指数低于对照组（3.2±1.6比4.5±2.1， P＜0.01）。治疗后，观察组临床症状评分少于对照组[（4.2±1.3）分比（6.8±2.2）分，P＜0.01]。观察组总有效率显著高于对照组总有效率（93.6％比74.6％，P＜0.01）。观察组复发率显著低于对照组（4.8％比17.5％，P ＜0.05）。治疗后，观察组患者血清 IL-10显著高于对照组[（109±31） ng／L比（89±29） ng／L，P＜0.01]。治疗后，观察组患者血清 IL-18显著低于对照组[（89±22） ng／L 比（128±30） ng／L，P＜0.01]。结论美沙拉嗪联合金双歧治疗溃疡性结肠炎疗效显著，复发率低，能够改善患者的症状、减轻炎症反应，且不良反应小。
목적：탐토미사랍진연합금쌍기치료궤양성결장염적료효급기대환자세포인자적영향。방법선택2010년1월지2014년1월재팽산현인민의원접수치료적궤양성결장염환자126례위연구대상，안조수궤수자표법분성용대조조화관찰조，각63례。대조조단순복용미사랍진，매차1 g，매일3차。관찰조복용미사랍진，매차1 g，매일3차；동시구복금쌍기치료，매차4립，매일3차。량조료정균위2개월。결과치료후，관찰조환자질병활동지수저우대조조（3.2±1.6비4.5±2.1， P＜0.01）。치료후，관찰조림상증상평분소우대조조[（4.2±1.3）분비（6.8±2.2）분，P＜0.01]。관찰조총유효솔현저고우대조조총유효솔（93.6％비74.6％，P＜0.01）。관찰조복발솔현저저우대조조（4.8％비17.5％，P ＜0.05）。치료후，관찰조환자혈청 IL-10현저고우대조조[（109±31） ng／L비（89±29） ng／L，P＜0.01]。치료후，관찰조환자혈청 IL-18현저저우대조조[（89±22） ng／L 비（128±30） ng／L，P＜0.01]。결론미사랍진연합금쌍기치료궤양성결장염료효현저，복발솔저，능구개선환자적증상、감경염증반응，차불량반응소。
Objective To study the effect of mesalazine combined with Bifidobacterium and Lactobacil-lus tablets treatment of ulcerative colitis and its effect on cytokines .Methods A total of 126 patients with ulcerative colitis from Pengshan People′s Hospital were who were randomly divided into control group and observation group,63 cases in each.The control group only took mesalazine,1 g/time,3 times a day.The observation group was treated with mesalazine and Bifidobacterium and Lactobacillus Tablets ,4 tablets/time, 3 times a day.The treatment course was two months for both groups.Results After treatment,the Disease Activity Index in the observation group was lower than the control group (3.2 ±1.6 vs 4.5 ±2.1,P <0.01).Clinical symptom scores in the observation group were lower than the control group [(4.2 ±1.3) scores vs (6.8 ±2.2) scores, P<0.01].The total effective rate in the observation group was significantly higher than the control group(93.6% vs 74.6%,P<0.01).Recurrence rate in the observation group was significantly lower than the control group(4.8% vs 17.5%, P <0.05).Serum IL-10 in the observation group was significantly higher than the control group[(109 ±31) ng/L vs (89 ±29) ng/L,P<0.01].After treatment,serum IL-18 in the observation group was significantly lower than the control group[(89 ±22) ng/L vs (128 ±30) ng/L,P<0.01].Conclusion Mesalazine combined with Bifidobacterium and Lactobacillus tablet treatment of ulcerative colitis has good curative effect and low recurrence rate ,which can improve the symptoms,reduce inflammation with less adverse effect .