中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2015年
14期
3-5
,共3页
老年冠心病%瘦素%中医证型
老年冠心病%瘦素%中醫證型
노년관심병%수소%중의증형
Elderly patients with coronary heart disease%Serum leptin levels%TCM Syndromes
目的：探讨老年冠心病患者的血清瘦素水平的变化及其与中医证候的相关性。方法：选取河南中医学院第一附属医院老年病科2012年2月-2014年2月收治的65例老年冠心病患者，根据病情分为稳定型心绞痛组（22例）、不稳定型心绞痛组（35例）及急性心肌梗死组（8例），并收集20例排除冠心病老年人作为对照组，应用ELISA法进行血清瘦素水平检测，并进行统计学分析。比较各组冠心病患者及对照组血清瘦素水平。将65例老年冠心病患者随机分入四个中医证型组，测定其空腹血清瘦素水平、血脂、体重指数等值，记录并评价指标。结果：血清瘦素水平冠心病各组明显高于正常对照组（P<0.05），不稳定型心绞痛组及急性心肌梗死组高于稳定型心绞痛组（P<0.05），急性心肌梗死组高于不稳定型心绞痛组（P<0.05），血清瘦素水平与冠心病病变程度呈正相关（r＝0.60，P<0.05），冠心病各组与正常对照组比较有统计学意义（P<0.05）。其中痰浊内阻证患者血清瘦素水平高于其他证型。结论：老年冠心病患者血清瘦素水平明显增高，血清瘦素水平检测对老年冠心病严重程度具有较好的预测价值。其水平增高与痰浊内阻型冠心病密切相关，冠心病患者血清瘦素水平升高为冠心病（胸痹）中医辨证分型的客观化研究提供了一个新的思路。
目的：探討老年冠心病患者的血清瘦素水平的變化及其與中醫證候的相關性。方法：選取河南中醫學院第一附屬醫院老年病科2012年2月-2014年2月收治的65例老年冠心病患者，根據病情分為穩定型心絞痛組（22例）、不穩定型心絞痛組（35例）及急性心肌梗死組（8例），併收集20例排除冠心病老年人作為對照組，應用ELISA法進行血清瘦素水平檢測，併進行統計學分析。比較各組冠心病患者及對照組血清瘦素水平。將65例老年冠心病患者隨機分入四箇中醫證型組，測定其空腹血清瘦素水平、血脂、體重指數等值，記錄併評價指標。結果：血清瘦素水平冠心病各組明顯高于正常對照組（P<0.05），不穩定型心絞痛組及急性心肌梗死組高于穩定型心絞痛組（P<0.05），急性心肌梗死組高于不穩定型心絞痛組（P<0.05），血清瘦素水平與冠心病病變程度呈正相關（r＝0.60，P<0.05），冠心病各組與正常對照組比較有統計學意義（P<0.05）。其中痰濁內阻證患者血清瘦素水平高于其他證型。結論：老年冠心病患者血清瘦素水平明顯增高，血清瘦素水平檢測對老年冠心病嚴重程度具有較好的預測價值。其水平增高與痰濁內阻型冠心病密切相關，冠心病患者血清瘦素水平升高為冠心病（胸痺）中醫辨證分型的客觀化研究提供瞭一箇新的思路。
목적：탐토노년관심병환자적혈청수소수평적변화급기여중의증후적상관성。방법：선취하남중의학원제일부속의원노년병과2012년2월-2014년2월수치적65례노년관심병환자，근거병정분위은정형심교통조（22례）、불은정형심교통조（35례）급급성심기경사조（8례），병수집20례배제관심병노년인작위대조조，응용ELISA법진행혈청수소수평검측，병진행통계학분석。비교각조관심병환자급대조조혈청수소수평。장65례노년관심병환자수궤분입사개중의증형조，측정기공복혈청수소수평、혈지、체중지수등치，기록병평개지표。결과：혈청수소수평관심병각조명현고우정상대조조（P<0.05），불은정형심교통조급급성심기경사조고우은정형심교통조（P<0.05），급성심기경사조고우불은정형심교통조（P<0.05），혈청수소수평여관심병병변정도정정상관（r＝0.60，P<0.05），관심병각조여정상대조조비교유통계학의의（P<0.05）。기중담탁내조증환자혈청수소수평고우기타증형。결론：노년관심병환자혈청수소수평명현증고，혈청수소수평검측대노년관심병엄중정도구유교호적예측개치。기수평증고여담탁내조형관심병밀절상관，관심병환자혈청수소수평승고위관심병（흉비）중의변증분형적객관화연구제공료일개신적사로。
Objective:To observe the changes in elderly patients with coronary artery disease and its relationship with serum leptin levels syndromes correlation. Methods:65 cases of elderly patients with coronary heart disease were divided into stable angina group (22 cases), unstable angina group (35 cases) and acute myocardial infarction group (eight cases), and collected 20 cases of coronary heart disease exclude older people as a control group, the application of serum leptin levels by ELISA testing and statistical analysis. Comparison of patients in each group and the control group, serum leptin levels coronary heart disease. The 65 cases of elderly patients with coronary heart disease were randomly divided into four groups syndromes, measured fasting serum leptin levels, cholesterol, body mass index equivalent, recording and evaluation. Results: Serum leptin levels were significantly higher than those with coronary heart disease each normal control group (P<0.05), unstable angina and acute myocardial infarction group than stable angina group (P<0.05), acute myocardial infarction, unstable angina group than in the group (P<0.05). Serum leptin levels and coronary artery disease severity was positively correlated (r=0.60, P<0.05). Coronary heart disease in each group and the normal control group was statistically significant (P<0.05). Phlegm resistance syndrome and syndrome Yang Qi decline in serum leptin levels were better than other syndromes. Conclusion:Serum leptin levels were significantly higher in elderly patients with coronary heart disease, serum leptin levels detected with better predictive value for the severity of coronary heart disease in elderly. It is closely related to increased levels of coronary heart disease with phlegm resistance, elevated serum leptin levels in patients with coronary heart disease is coronary artery disease (chest stuffiness) TCM type of objective study provides a new way of thinking.
