医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2015年
12期
2286-2288
,共3页
大肠癌%标志物%C反应蛋白%糖类抗原125%糖类抗原19-9%糖类抗原72-4
大腸癌%標誌物%C反應蛋白%糖類抗原125%糖類抗原19-9%糖類抗原72-4
대장암%표지물%C반응단백%당류항원125%당류항원19-9%당류항원72-4
Colorectal cancer%Marker%C-reactive protein%Carbohydrate antigen 125%Carbohydrate antigen 19-9%Carbohydrate antigen 72-4
目的：探讨血清C反应蛋白（CRP）、糖类抗原（CA）125、CA19-9和 CA72-4联合检测对诊断大肠癌的临床价值。方法收集2013年2～12月武汉市第八医院收治的44例大肠癌患者作为大肠癌组，大肠息肉患者28例为大肠息肉组，另外选取30例同期健康体检者作为正常对照组，采用免疫比浊法和电化学发光法对大肠癌组手术前后、大肠息肉组和正常对照组血清 CRP、CA125、CA19-9和CA72-4水平进行检测。结果大肠癌组患者血清中4种标志物水平显著高于正常对照组（ P ＜0.05），且大肠癌组患者血清中CA125、CA19-9和CA72-4水平显著高于大肠息肉组（P＜0.05）。大肠癌Dukes C～D期患者4种标志物水平显著高于Dukes A～B期患者（P＜0.01），同时大肠癌高、中分化患者4种标志物水平与低分化组比较，差异有统计学意义（ P＜0.01）。4种标志物联合检测对大肠癌诊断的灵敏度和准确度显著高于单一标志物。大肠癌患者作根治性切除术后1个月4种标志物水平较术前显著降低（ P＜0.05）。结论联合检测血清 CRP、CA125、CA19-9和 CA72-4水平可作为大肠癌的早期诊断、手术方法的选择、疗效评价及预后监测有意义的参考指标。
目的：探討血清C反應蛋白（CRP）、糖類抗原（CA）125、CA19-9和 CA72-4聯閤檢測對診斷大腸癌的臨床價值。方法收集2013年2～12月武漢市第八醫院收治的44例大腸癌患者作為大腸癌組，大腸息肉患者28例為大腸息肉組，另外選取30例同期健康體檢者作為正常對照組，採用免疫比濁法和電化學髮光法對大腸癌組手術前後、大腸息肉組和正常對照組血清 CRP、CA125、CA19-9和CA72-4水平進行檢測。結果大腸癌組患者血清中4種標誌物水平顯著高于正常對照組（ P ＜0.05），且大腸癌組患者血清中CA125、CA19-9和CA72-4水平顯著高于大腸息肉組（P＜0.05）。大腸癌Dukes C～D期患者4種標誌物水平顯著高于Dukes A～B期患者（P＜0.01），同時大腸癌高、中分化患者4種標誌物水平與低分化組比較，差異有統計學意義（ P＜0.01）。4種標誌物聯閤檢測對大腸癌診斷的靈敏度和準確度顯著高于單一標誌物。大腸癌患者作根治性切除術後1箇月4種標誌物水平較術前顯著降低（ P＜0.05）。結論聯閤檢測血清 CRP、CA125、CA19-9和 CA72-4水平可作為大腸癌的早期診斷、手術方法的選擇、療效評價及預後鑑測有意義的參攷指標。
목적：탐토혈청C반응단백（CRP）、당류항원（CA）125、CA19-9화 CA72-4연합검측대진단대장암적림상개치。방법수집2013년2～12월무한시제팔의원수치적44례대장암환자작위대장암조，대장식육환자28례위대장식육조，령외선취30례동기건강체검자작위정상대조조，채용면역비탁법화전화학발광법대대장암조수술전후、대장식육조화정상대조조혈청 CRP、CA125、CA19-9화CA72-4수평진행검측。결과대장암조환자혈청중4충표지물수평현저고우정상대조조（ P ＜0.05），차대장암조환자혈청중CA125、CA19-9화CA72-4수평현저고우대장식육조（P＜0.05）。대장암Dukes C～D기환자4충표지물수평현저고우Dukes A～B기환자（P＜0.01），동시대장암고、중분화환자4충표지물수평여저분화조비교，차이유통계학의의（ P＜0.01）。4충표지물연합검측대대장암진단적령민도화준학도현저고우단일표지물。대장암환자작근치성절제술후1개월4충표지물수평교술전현저강저（ P＜0.05）。결론연합검측혈청 CRP、CA125、CA19-9화 CA72-4수평가작위대장암적조기진단、수술방법적선택、료효평개급예후감측유의의적삼고지표。
Objective To explore the clinical value of combined testing of the serum levels of C-reactive protein(CRP),carbohydrate antigen (CA) 125,CA19-9,CA72-4 for colorectal cancer.Methods A total of 44 cases of colorectal cancer were collected from Wuhan Eighth Hospital from Feb.2013 to Dec.2013 were included as colorectal cancer group,28 cases of colorectal polyps were included as colorectal polyps group, and 30 persons for health checkup during the same period were included as normal control group.Serum lev-els of CRP,CA125,CA19-9,CA72-4 were detected by immunoturbidimetry method and the electrochemical luminescence assay in colorectal cancer group before and after operation,colorectal polyps group and control group.Results The levels of four markers in the serum of the patient with colorectal cancer were significantly higher than those in the healthy control group(P<0.05).The levels of CA125,CA19-9,CA72-4 in the ser-um of the patients with colorectal cancer were significantly higher than those in the colorectal polyp group (P<0.05).The levels of four markers in the serum of Dukes C-D stages of the colorectal cancer patients were significantly higher than those of Dukes A-B stages(P<0.01).Meanwhile,the levels of four markers in the serum of medium-high differentiated cancer and low differentiated cancer were statistically significantly different(P<0.01).The sensitivity and accuracy to the diagnosis of colorectal cancer with the four kinds of markers were signficantly higher than the single marker .The levels of the four serum markers declined remarkably one month after radical operation(P<0.05).Conclusion Combined detection of serum CRP, CA125,CA19-9 and CA72-4 levels can be used as indicators of early diagnosis,selection of operative meth-od,effect evaluation and prognosis monitoring for colorectal cancer.
