CAJ | 학술논문

目的：探讨脾氨肽口服冻干粉对儿童反复呼吸道感染（ RRI）患者的临床疗效以及 T淋巴细胞亚群功能的影响。方法收集2010年1月至2013年12月在深圳市宝安区福永人民医院诊治的RRI 患儿95例作为研究对象，按照随机数字表法分为脾氨肽治疗组（49例）和常规治疗组（46例），两组均予以常规抗感染、抗病毒、对症治疗，脾氨肽治疗组在此基础上给予脾氨肽冻干粉治疗，观察两组治疗效果，并于治疗前后分别检测分析患儿 T 细胞亚群变化情况。结果脾氨肽治疗组总有效率为73.5％，常规治疗组为52.2％，两组差异有统计学意义（P＜0.05），脾氨肽治疗组治疗后CD3＋、CD4＋百分比以及CD4＋／CD8＋比值显著降低（P＜0.05），CD8＋百分比增加（P＜0.01），与常规治疗组比较差异有统计学意义（P＜0.01）。结论脾氨肽口服冻干粉能增强 RRI 患儿的免疫功能，对治疗和预防RRI具有重要临床意义。
목적：탐토비안태구복동간분대인동반복호흡도감염（ RRI）환자적림상료효이급 T림파세포아군공능적영향。방법수집2010년1월지2013년12월재심수시보안구복영인민의원진치적RRI 환인95례작위연구대상，안조수궤수자표법분위비안태치료조（49례）화상규치료조（46례），량조균여이상규항감염、항병독、대증치료，비안태치료조재차기출상급여비안태동간분치료，관찰량조치료효과，병우치료전후분별검측분석환인 T 세포아군변화정황。결과비안태치료조총유효솔위73.5％，상규치료조위52.2％，량조차이유통계학의의（P＜0.05），비안태치료조치료후CD3＋、CD4＋백분비이급CD4＋／CD8＋비치현저강저（P＜0.05），CD8＋백분비증가（P＜0.01），여상규치료조비교차이유통계학의의（P＜0.01）。결론비안태구복동간분능증강 RRI 환인적면역공능，대치료화예방RRI구유중요림상의의。
Objective To observe the clinical effect of spleen aminopeptide oral lyophilized powder in the treatment of pediatric repeated respiratory infection ( RRI) and its influence on T lymphocyte subset. Methods A total of 95 RRT children in Fuyong People′s Hospital from Jan.2010 to Dec.2013 were included as research objects,and were divided into spleen aminopeptide treatment group and conventional treatment group according to random number-table method.Both groups were given conventional anti-infection and symptomatic treatment,while the spleen aminopeptide treatment group was given additional spleen aminopep-tide lyophilized powder.T cell subgroup and clinical effect were detected before and after treatment.Results Total effective rate of spleen aminopeptide treatment group and conventional treatment group was 73.5% and 52.2% respectively,the difference was statistically significant(P <0.05);the percentage of CD3 +,CD4 +, CD4 +/CD8 +of spleen aminopeptide treatment group were obviously lower than that in the conventional treatment group(P<0.05),and CD8 +percentage was higher than the conventional treatment group(P <0.01).Conclusion Spleen aminopeptide oral lyophilized powder can strengthen immunologic function in RRI children,which has great clinical significance for the treatment and prevention of RRI.