临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
18期
16-17
,共2页
肠易激综合征%谷维素%马来酸曲美布汀%治疗结果
腸易激綜閤徵%穀維素%馬來痠麯美佈汀%治療結果
장역격종합정%곡유소%마래산곡미포정%치료결과
Irritable bowel syndrome%Oryzanol%Trimebutine maleate%Treatment outcome
目的：探讨谷维素联合马来酸曲美布汀治疗肠易激综合征（ IBS）的临床疗效。方法选取2012年5月—2014年8月株洲市三三一医院收治的 IBS 患者67例，按治疗方法不同将患者分为治疗组（35例）与对照组（32例）。对照组患者予以马来酸曲美布汀治疗，治疗组患者在对照组基础上加用谷维素治疗。观察两组患者临床疗效、治疗前后症状评分和症状频率评分、不良反应发生情况。结果治疗组患者总有效率高于对照组，差异有统计学意义（P ﹤0.01）；治疗前两组患者症状评分和症状频率评分比较，差异无统计学意义（ P ﹥0.05），治疗后治疗组患者症状评分和症状频率评分低于对照组，差异有统计学意义（ P ﹤0.05）；两组患者不良反应发生率比较，差异无统计学意义（P ﹥0.05）。结论谷维素联合马来酸曲美布汀治疗 IBS 的临床疗效显著，可改善患者肠道功能，且不良反应小。
目的：探討穀維素聯閤馬來痠麯美佈汀治療腸易激綜閤徵（ IBS）的臨床療效。方法選取2012年5月—2014年8月株洲市三三一醫院收治的 IBS 患者67例，按治療方法不同將患者分為治療組（35例）與對照組（32例）。對照組患者予以馬來痠麯美佈汀治療，治療組患者在對照組基礎上加用穀維素治療。觀察兩組患者臨床療效、治療前後癥狀評分和癥狀頻率評分、不良反應髮生情況。結果治療組患者總有效率高于對照組，差異有統計學意義（P ﹤0.01）；治療前兩組患者癥狀評分和癥狀頻率評分比較，差異無統計學意義（ P ﹥0.05），治療後治療組患者癥狀評分和癥狀頻率評分低于對照組，差異有統計學意義（ P ﹤0.05）；兩組患者不良反應髮生率比較，差異無統計學意義（P ﹥0.05）。結論穀維素聯閤馬來痠麯美佈汀治療 IBS 的臨床療效顯著，可改善患者腸道功能，且不良反應小。
목적：탐토곡유소연합마래산곡미포정치료장역격종합정（ IBS）적림상료효。방법선취2012년5월—2014년8월주주시삼삼일의원수치적 IBS 환자67례，안치료방법불동장환자분위치료조（35례）여대조조（32례）。대조조환자여이마래산곡미포정치료，치료조환자재대조조기출상가용곡유소치료。관찰량조환자림상료효、치료전후증상평분화증상빈솔평분、불량반응발생정황。결과치료조환자총유효솔고우대조조，차이유통계학의의（P ﹤0.01）；치료전량조환자증상평분화증상빈솔평분비교，차이무통계학의의（ P ﹥0.05），치료후치료조환자증상평분화증상빈솔평분저우대조조，차이유통계학의의（ P ﹤0.05）；량조환자불량반응발생솔비교，차이무통계학의의（P ﹥0.05）。결론곡유소연합마래산곡미포정치료 IBS 적림상료효현저，가개선환자장도공능，차불량반응소。
Objective To explore the effect of oryzanol combined with trimebutine maleate in treating irritable bowel syndrome(IBS). Methods A total of 67 patients with IBS were selected in the 33 / st Hospital of Zhuzhou from May 2012 to August 2014,according to the differences of the treatment measures,they were divided into the treatment group(35 cases)and control group(32 cases). Ccontrol group were given trimebutine maleate treatment,treatment group were given oryzanol treat-ment on the basis of control group. Before and after treatment,clinical effect,symptom score,frequency of symptoms score and incidence of adverse reactions were compared. Results The total effective rate of treatment group was higher than that of the control group(P ﹤ 0. 01);before treatment,symptom scores and frequency of symptoms score showed no significant differences between the two groups(P ﹥ 0. 05),after treatment,symptom scores and frequency of symptoms score of treatment were lower than those of control group(P ﹤ 0. 05);incidence of adverse reactions showed no significant differences between the two groups (P ﹥ 0. 05). Conclusion Oryzanol combined with trimebutine maleate has notable curative effect in the treatment of irritable bowel syndrome,can improve intestinal function,have less adverse reactions.
