医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2015年
12期
2255-2256
,共2页
宫颈癌%奈达铂%顺铂%5-氟尿嘧啶%同步放化疗
宮頸癌%奈達鉑%順鉑%5-氟尿嘧啶%同步放化療
궁경암%내체박%순박%5-불뇨밀정%동보방화료
Cervical cancer%Nedaplatin%Cisplatin%5-Fluorouracil%Concurrent radiochemotherapy
目的：探讨奈达铂、顺铂与5-氟尿嘧啶联合治疗中晚期宫颈癌患者的疗效及安全性。方法选取2009年5月至2011年5月在湖南省肿瘤医院确诊的中晚期宫颈癌患者86例，采用随机数字表法随机均分为两组，各43例，分别行奈达铂＋5-氟尿嘧啶同步放化疗（奈达铂组）与顺铂＋5-氟尿嘧啶同步放化疗（顺铂组），观察记录不良反应和疗效。结果奈达铂组41例有效，有效率为95.4％；顺铂组32例有效，有效率为74.4％，两组近期疗效比较差异有统计学意义（ P＜0.05），奈达铂组复发率显著低于顺铂组[7.0％（5／43）比25.6％（11／43），P＜0.05]，奈达铂组Ⅲ～Ⅳ度白细胞减少发生率显著低于顺铂组[9.3％（4／43）比32.6％（14／43），P＜0.01]。结论奈达铂＋5-氟尿嘧啶同步放化疗比顺铂＋5-氟尿嘧啶同步放化疗具有更好的疗效，更少的不良反应。
目的：探討奈達鉑、順鉑與5-氟尿嘧啶聯閤治療中晚期宮頸癌患者的療效及安全性。方法選取2009年5月至2011年5月在湖南省腫瘤醫院確診的中晚期宮頸癌患者86例，採用隨機數字錶法隨機均分為兩組，各43例，分彆行奈達鉑＋5-氟尿嘧啶同步放化療（奈達鉑組）與順鉑＋5-氟尿嘧啶同步放化療（順鉑組），觀察記錄不良反應和療效。結果奈達鉑組41例有效，有效率為95.4％；順鉑組32例有效，有效率為74.4％，兩組近期療效比較差異有統計學意義（ P＜0.05），奈達鉑組複髮率顯著低于順鉑組[7.0％（5／43）比25.6％（11／43），P＜0.05]，奈達鉑組Ⅲ～Ⅳ度白細胞減少髮生率顯著低于順鉑組[9.3％（4／43）比32.6％（14／43），P＜0.01]。結論奈達鉑＋5-氟尿嘧啶同步放化療比順鉑＋5-氟尿嘧啶同步放化療具有更好的療效，更少的不良反應。
목적：탐토내체박、순박여5-불뇨밀정연합치료중만기궁경암환자적료효급안전성。방법선취2009년5월지2011년5월재호남성종류의원학진적중만기궁경암환자86례，채용수궤수자표법수궤균분위량조，각43례，분별행내체박＋5-불뇨밀정동보방화료（내체박조）여순박＋5-불뇨밀정동보방화료（순박조），관찰기록불량반응화료효。결과내체박조41례유효，유효솔위95.4％；순박조32례유효，유효솔위74.4％，량조근기료효비교차이유통계학의의（ P＜0.05），내체박조복발솔현저저우순박조[7.0％（5／43）비25.6％（11／43），P＜0.05]，내체박조Ⅲ～Ⅳ도백세포감소발생솔현저저우순박조[9.3％（4／43）비32.6％（14／43），P＜0.01]。결론내체박＋5-불뇨밀정동보방화료비순박＋5-불뇨밀정동보방화료구유경호적료효，경소적불량반응。
Objective To explore the therapeutic effect and safety of the combination of nedaplatin or cisplatin and 5-fluorouracil for treatment of advanced cervical cancer.Methods A total of 86 patients with confirmed diagnosis of advanced cervical cancer in Hunan Cancer Hospital from May 2009 to May 2011 were included.They were randomly divided into two groups by random number table method ,43 patients in each group.The nedaplatin group was given nedaplatin plus 5-fluorouracil concurrent radiochemotherapy,the other group was given cisplatin plus 5-fluorouracil concurrent radiochemotherapy.The adverse effects and therapeu-tic effects were observed and recorded.Results In nedaplatin group there were 41 cases of effective,and the effective rate was 95.4%;in cisplatin group there were 32 cases of effective, and the effective rate was 74.4%,the differences of short-term effects between the two groups were significant(P<0.05).Recurrence rate of nedaplatin group was lower than cisplatin group[7.0%(5/43) vs 25.6%(11/43),P<0.05],Ⅲ,Ⅳ WBC decreases of nedaplatin group was lower than cisplatin group[9.3%(4/43) vs 32.6%(14/43), P<0.01].Conclusion Compared to cisplatin plus 5-fluorouracil concurrent radiochemotherapy,nedaplatin plus 5-fluorouracil concurrent radiochemotherapy has better curative effects and less adverse effect .
