CAJ | 학술논문

目的：探讨厄贝沙坦片联合盐酸贝尼地平片治疗高血压肾病的临床疗效。方法选取2011年1月—2014年1月魏县人民医院收治的高血压肾病患者132例，采用随机数字表法将患者分为厄贝沙坦组（49例），贝尼地平组（43例），联合治疗组（40例）。厄贝沙坦组患者予以厄贝沙坦片治疗；贝尼地平组患者予以盐酸贝尼地平片治疗；联合治疗组患者予以厄贝沙坦片联合盐酸贝尼地平片治疗。观察3组患者治疗前后血压、肾功能〔24h 尿蛋白定量、血肌酐（Scr）、血尿素氮（BUN）、内生肌酐清除率（Ccr）〕及不良反应发生情况。结果治疗前3组患者收缩压、舒张压、24h 尿蛋白定量、Scr、BUN、Ccr 比较，差异无统计学意义（P ﹥0.05）；治疗后3组患者收缩压、舒张压、24h 尿蛋白定量、Scr、BUN、Ccr 比较，差异有统计学意义（ P ﹤0.05）；联合治疗组患者收缩压、舒张压、24h 尿蛋白定量、Scr、BUN 低于厄贝沙坦组和贝尼地平组，Ccr 高于厄贝沙坦组和贝尼地平组，差异有统计学意义（P ﹤0.05）；3组患者不良反应发生率比较，差异无统计学意义（P ﹥0.05）。结论厄贝沙坦联合贝尼地平治疗高血压肾病的临床疗效显著，可改善患者临床症状，且不良反应小。
목적：탐토액패사탄편연합염산패니지평편치료고혈압신병적림상료효。방법선취2011년1월—2014년1월위현인민의원수치적고혈압신병환자132례，채용수궤수자표법장환자분위액패사탄조（49례），패니지평조（43례），연합치료조（40례）。액패사탄조환자여이액패사탄편치료；패니지평조환자여이염산패니지평편치료；연합치료조환자여이액패사탄편연합염산패니지평편치료。관찰3조환자치료전후혈압、신공능〔24h 뇨단백정량、혈기항（Scr）、혈뇨소담（BUN）、내생기항청제솔（Ccr）〕급불량반응발생정황。결과치료전3조환자수축압、서장압、24h 뇨단백정량、Scr、BUN、Ccr 비교，차이무통계학의의（P ﹥0.05）；치료후3조환자수축압、서장압、24h 뇨단백정량、Scr、BUN、Ccr 비교，차이유통계학의의（ P ﹤0.05）；연합치료조환자수축압、서장압、24h 뇨단백정량、Scr、BUN 저우액패사탄조화패니지평조，Ccr 고우액패사탄조화패니지평조，차이유통계학의의（P ﹤0.05）；3조환자불량반응발생솔비교，차이무통계학의의（P ﹥0.05）。결론액패사탄연합패니지평치료고혈압신병적림상료효현저，가개선환자림상증상，차불량반응소。
Objective To explore the effect of irbesartan and benidipine hydrochloride in treating hypertensive ne-phropathy. Methods A total of 132 patients with hypertensive nephropathy were selected in the People's Hospital of Wei Coun-try from January 2011 to January 2014,according to the random number table,they were divided into irbesartan group(49 ca-ses),benidipine group(43 cases),combined treatment group(40 cases). Irbesartan group were given irbesartan treatment, benidipine group were given benidipine hydrochloride treatment,combined treatment group were given irbesartan and benidipine hydrochloride treatment. Before and after treatment,blood pressure,renal function〔24 hour urinary protein quantity,serum creatinine(Scr),blood urea nitrogen(BUN),endogenous creatinine clearance rate(Ccr)〕and incidence of adverse reac-tions were compared. Results Before treatment,systolic pressure,diastolic blood pressure,24 hour urinary protein quantity, Scr,BUN,Ccr showed no significant differences in the three groups(P ﹥ 0. 05);after treatment,systolic pressure,diastolic blood pressure,24 hour urinary protein quantity,Scr,BUN,Ccr showed significant differences in the three groups( P ﹤0. 05);systolic pressure,diastolic blood pressure,24 hour urinary protein quantity,Scr,BUN of combined treatment group were lower than those of irbesartan group and benidipine group,Ccr of combined treatment group was higher than that of irbesar-tan group and benidipine group(P ﹤ 0. 05);incidence of adverse reactions showed no significant differences in the three groups (P ﹥ 0. 05). Conclusion Irbesartan and benidipine hydrochloride has notable curative effect in the treatment of hypertensive nephropathy,can improve the clinical symptoms and has less adverse reactions.