CAJ | 학술논문

目的：比较不同剂量阿托伐他汀对老年急性冠状动脉综合征（ ACS）患者血脂及血清高敏C反应蛋白（ hs-CRP）的影响。方法将2011年1月至2013年12月在承德市中心医院老年病科就诊的160例ACS患者按照随机数字表法分为观察组和对照组，每组80例。两组患者均给予常规治疗，观察组在常规治疗基础上给予阿托伐他汀强化剂量（40 mg／d）治疗，对照组在常规治疗的基础上给予阿托伐他汀常规剂量（20 mg／d ）治疗。比较两组患者治疗12周内不良事件发生率以及治疗12周总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和hs-CRP水平。结果两组不良事件发生率比较差异无统计学意义（ P＞0.05）。治疗12周后，观察组TC、LDL-C 水平分别为（3.15±0.65） mmol／L、（2.38±0.35） mmol／L，低于对照组的（3.98±0.64） mmol／L、（3.11±0.37） mmol／L，差异有统计学意义（P＜0.01）；治疗12周后，观察组血清 hs-CRP水平为（2.45±1.06） mg／L，显著低于对照组的（3.33±1.22） mg／L，差异有统计学意义（P＜0.01）。结论阿托伐他汀强化剂量可改善血脂水平，降低血清hs-CRP水平。
목적：비교불동제량아탁벌타정대노년급성관상동맥종합정（ ACS）환자혈지급혈청고민C반응단백（ hs-CRP）적영향。방법장2011년1월지2013년12월재승덕시중심의원노년병과취진적160례ACS환자안조수궤수자표법분위관찰조화대조조，매조80례。량조환자균급여상규치료，관찰조재상규치료기출상급여아탁벌타정강화제량（40 mg／d）치료，대조조재상규치료적기출상급여아탁벌타정상규제량（20 mg／d ）치료。비교량조환자치료12주내불량사건발생솔이급치료12주총담고순（TC）、저밀도지단백담고순（LDL-C）화hs-CRP수평。결과량조불량사건발생솔비교차이무통계학의의（ P＞0.05）。치료12주후，관찰조TC、LDL-C 수평분별위（3.15±0.65） mmol／L、（2.38±0.35） mmol／L，저우대조조적（3.98±0.64） mmol／L、（3.11±0.37） mmol／L，차이유통계학의의（P＜0.01）；치료12주후，관찰조혈청 hs-CRP수평위（2.45±1.06） mg／L，현저저우대조조적（3.33±1.22） mg／L，차이유통계학의의（P＜0.01）。결론아탁벌타정강화제량가개선혈지수평，강저혈청hs-CRP수평。
Objective To compare the effect of different doses of atorvastatin for elderly patients with acute coronary syndrome in lipids and serum high sensitivity C reactive protein(hs-CRP).Methods A total of 160 elderly patients with acute coronary syndrome admitted to the Chengde Central Hospital from Jan .2011 to Dec.2013 were randomly divided into observation group (80 cases) and control group (80 cases) accord-ing to the random number table method.Both groups were given conventional treatment,while the observation group was also given intensive atorvastatin at dose 40 mg/d,and the control group was given atorvastatin at routine dose 20 mg/d.The incidence of adverse events within 12 weeks and total cholesterol(TC),low density lipoprotein cholesterol (LDL-C) levels and serum hs-CRP level of the two groups at 12 weeks were com-pared.Results The incidence of adverse reactions of two groups was not statistically significant ( P >0.05).TC, LDL-C levels of the observation group after 12 weeks of treatment were (3.15 ±0.65) mmol/L, (2.38 ±0.35) mmol/L,which were lower than (3.98 ±0.64) mmol/L,(3.11 ±0.37) mmol/L of the con-trol group, the differences were statistically significant(P<0.01).The serum hs-CRP concentration of the observation group was (2.45 ±1.06) mg/L after 12 weeks of treatment, significantly lower than (3.33 ± 1.22) mg/L of the control group,the difference was statistically significant(P<0.01).Conclusion Inten-sive atorvastatin dose can improve the blood lipid levels,and reduce the level of serum hs-CRP.