CAJ | 학술논문

神经系统变性疾病为一类缓慢起病、病程呈进行性发展、预后不良的疾病。近年来，神经变性疾病的发病率逐步上升。但是，临床上对于该类疾病还没有十分有效的治疗方法，其发机制也未完全清楚。随着体细胞重编程技术的进步，疾病特异性诱导性多能干细胞被逐渐应用于神经变性疾病发病机制、药物筛选及临床治疗方法的研究。然而，体细胞重编程技术尚处于早期级阶段，诱导性多能干细胞存在潜在的致癌风险及产生效率较低等问题，未来研究人员将致力于建立安全、高效、符合临床标准的诱导性多能干细胞。
신경계통변성질병위일류완만기병、병정정진행성발전、예후불량적질병。근년래，신경변성질병적발병솔축보상승。단시，림상상대우해류질병환몰유십분유효적치료방법，기발궤제야미완전청초。수착체세포중편정기술적진보，질병특이성유도성다능간세포피축점응용우신경변성질병발병궤제、약물사선급림상치료방법적연구。연이，체세포중편정기술상처우조기급계단，유도성다능간세포존재잠재적치암풍험급산생효솔교저등문제，미래연구인원장치력우건립안전、고효、부합림상표준적유도성다능간세포。
Neurodegenerative disease is characterized by slow onset,progressive development and poor prognosis.In recent years,the morbidity of neurodegenerative disease is rising constantly.But there is still no effective clinical therapy, and their pathogenesis remains unclear.Along with the progress of the technology of somatic cell reprogramming,patient-specific induced pluripotent stem cells(iPSC) have been gradually applied as in vitro models for the study of the pathogenesis of neurodegenerative diseases ,drug screening and clinical treatment.However,the technology of somatic cell reprogramming is still in its early stages,and there are still problems such as potential carcinogenic risk and low productivity etc ., therefore the researchers should be devoted to establishing safe,efficient and clinically qualified iPSC .