CAJ | 학술논문

脂联素是存在于白脂肪组织和棕脂肪组织中的激素，通过结合脂联素受体1，2及 T-钙黏蛋白发挥作用。脂联素与肥胖、非酒精性脂肪肝（NAFLD）、糖尿病以及其他胰岛素抵抗状态呈负相关。脂联素缺乏除了会导致代谢紊乱外，还可引发冠状动脉硬化性心脏病、脂肪肝炎、胰岛素抵抗、NAFLD以及多种癌症。脂联素能调节多项细胞通路，如脂联素在肝脏及肌肉中具有增强腺苷酸活化蛋白激酶及过氧化物酶体增殖物激活受体α通路的作用。该文就脂联素与代谢性疾病的关系予以综述。
지련소시존재우백지방조직화종지방조직중적격소，통과결합지련소수체1，2급 T-개점단백발휘작용。지련소여비반、비주정성지방간（NAFLD）、당뇨병이급기타이도소저항상태정부상관。지련소결핍제료회도치대사문란외，환가인발관상동맥경화성심장병、지방간염、이도소저항、NAFLD이급다충암증。지련소능조절다항세포통로，여지련소재간장급기육중구유증강선감산활화단백격매급과양화물매체증식물격활수체α통로적작용。해문취지련소여대사성질병적관계여이종술。
Adiponectin is a hormone existing in white and brown adipose tissues and acts through bind-ing to its receptors adipoR1,AdipoR2,and T-cadheri.Adiponectin is negatively correlated with obesity,dia-betes,nonalcoholic fatty liver disease(NAFLD) and other insulin-resistant states.Apart from causing meta-bolic dysfunction,adiponectin deficiency may also contribute to coronary heart disease,steatohepatitis,insulin resistance,NAFLD,and a wide array of cancers.Adiponectin can mediate multiple molecular pathways,such as enhancing AMP-activated protein kinase and peroxisome proliferator activated receptor αpathway in the liver and skeletal muscle.Here is to make a review of the relationship between adiponectin and metabolic dysfunction.