CAJ | 학술논문

结核分枝杆菌是结核病的致病菌，机体免疫反应在结核菌的防御和致病中发挥关键调控作用。模式识别受体家族中的Toll样受体（ TLRs）能感知结核杆菌感染，并参与调控天然免疫和获得性免疫应答；而TLRs 亦能介导结核分枝杆菌的免疫逃避机制过程，促进慢性感染的发生、发展。利用免疫佐剂调控TLRs的功能水平可能有助于增强机体抗结核反应，并有望成为结核病预防和治疗的方向。
결핵분지간균시결핵병적치병균，궤체면역반응재결핵균적방어화치병중발휘관건조공작용。모식식별수체가족중적Toll양수체（ TLRs）능감지결핵간균감염，병삼여조공천연면역화획득성면역응답；이TLRs 역능개도결핵분지간균적면역도피궤제과정，촉진만성감염적발생、발전。이용면역좌제조공TLRs적공능수평가능유조우증강궤체항결핵반응，병유망성위결핵병예방화치료적방향。
Mycobacterium tuberculosis is the pathogenic agent of tuberculosis.The host immune respon-ses have critical regulation effect on the defense and pathogenesis of tuberculosis.Toll-like receptors(TLRs), belonging to pattern recognition receptors family,act as key sensors of mycobacterial infections and can regu-late innate immunity and adaptive immunity.Besides,TLRs participate in the immune evasion process of my-cobacterium tuberculosis,so as to facilitate the incidence and development of chronic infection.The immune-adjuvant may help to regulate function of TLRs to enhance the host immune response and would become new direction for the prevention and treatment of tuberculosis.