CAJ | 학술논문

出血和血栓并发症是导致急性早幼粒细胞白血病（ APL）患者死亡的主要因素。在出血及凝血功能紊乱发生、发展中，组织因子（ TF）的高表达可以造成患者血液高凝，进一步促进凝血紊乱的发生。 TF的高表达与早幼粒细胞白血病／维甲酸受体、细胞因子和细胞膜表面磷脂酰丝氨酸暴露密切相关。作为凝血活化的交汇点，选择性抑制TF对改善APL 出凝血紊乱和弥散性血管内凝血发生极为重要。
출혈화혈전병발증시도치급성조유립세포백혈병（ APL）환자사망적주요인소。재출혈급응혈공능문란발생、발전중，조직인자（ TF）적고표체가이조성환자혈액고응，진일보촉진응혈문란적발생。 TF적고표체여조유립세포백혈병／유갑산수체、세포인자화세포막표면린지선사안산폭로밀절상관。작위응혈활화적교회점，선택성억제TF대개선APL 출응혈문란화미산성혈관내응혈발생겁위중요。
Hemorrhage and thrombotic complications are the major causes for mortality in patients withacute promyelocytic leukemia(APL).During the incidence and development of hemorrhage and coagulopathy,highly expressed tissue factor(TF) can initiate the hypercoagulability and lead to coagulopathy and fatalhemorrhage.The high expression of TF is closely related with promyelocytic leukemia /retinoic acid receptorα,cytokines and phosphatidylserine exposure in membrane surfaces.Selective inhibition of TF,the intersectionof coagulation activation,plays an important role in improving APL hemostatic dysfunction and disseminatedintravascular coagulation.